Hemodynamic Assessment of underLying myocyTe Function in Right Heart Failure
Johns Hopkins University
50 participants
Dec 10, 2024
OBSERVATIONAL
Conditions
Summary
Right ventricular (RV) failure is recognized to worsen patient outcomes in the setting of heart failure with reduced ejection fraction (HFrEF)-related pulmonary hypertension (PH), yet the investigators fall short in trying to identify and treat it. The current proposal will (1) determine the best clinical indicators of intrinsic RV myocyte contractile failure in humans with HFrEF-PH, (2) clarify underlying mechanisms, and (3) test novel treatments on RV myocytes. The long-term goal of this proposal will be to better identify and treat RV failure in humans suffering from HFrEF-PH.
Eligibility
Plain Language Summary
Simplified for easier understanding
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Locations(1)
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NCT06299436