RecruitingNCT06299436

Hemodynamic Assessment of underLying myocyTe Function in Right Heart Failure


Sponsor

Johns Hopkins University

Enrollment

50 participants

Start Date

Dec 10, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

Right ventricular (RV) failure is recognized to worsen patient outcomes in the setting of heart failure with reduced ejection fraction (HFrEF)-related pulmonary hypertension (PH), yet the investigators fall short in trying to identify and treat it. The current proposal will (1) determine the best clinical indicators of intrinsic RV myocyte contractile failure in humans with HFrEF-PH, (2) clarify underlying mechanisms, and (3) test novel treatments on RV myocytes. The long-term goal of this proposal will be to better identify and treat RV failure in humans suffering from HFrEF-PH.


Eligibility

Min Age: 18 YearsMax Age: 90 Years

Plain Language Summary

Simplified for easier understanding

This study assesses heart function in detail using specialized cardiac monitoring in adults with reduced heart pumping function (heart failure with reduced ejection fraction) to better understand what is happening at the cellular level in the right side of the heart. **You may be eligible if...** - You are 18–90 years old with a confirmed diagnosis of heart failure with reduced ejection fraction (left ventricle pumps 40–50% or less) - You can safely pause blood-thinning medications for 48 hours before the procedure **You may NOT be eligible if...** - Your blood thinners cannot be safely paused (especially vitamin K antagonists with an INR above 1.5) - You are pregnant - You were hospitalized or had a flare-up of heart failure within the past 2 weeks - You are currently in another drug trial - You cannot lie flat - You have unstable blood pressure or circulation at rest Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(1)

Johns Hopkins Hospital

Baltimore, Maryland, United States

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NCT06299436


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