RecruitingPhase 2NCT07333183

A Study of Mosliciguat in Combination With Inhaled Treprostinil in PH-ILD

An Open-Label, Phase 2 Study Evaluating the Safety of Mosliciguat in Combination With Inhaled Treprostinil in Participants With Pulmonary Hypertension Associated With Interstitial Lung Disease


Sponsor

Pulmovant, Inc.

Enrollment

20 participants

Start Date

Dec 23, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This is a Phase 2, open-label, multi-center clinical study to evaluate the safety and tolerability of inhaled mosliciguat in participants with pulmonary hypertension associated with interstitial lung disease (PH-ILD) on a background inhaled treprostinil.


Eligibility

Min Age: 18 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether adding a new drug called mosliciguat to an existing inhaled medication (treprostinil) improves outcomes for people with pulmonary hypertension caused by interstitial lung disease (PH-ILD) — a condition where high blood pressure in the lungs is caused by scarring of the lung tissue. **You may be eligible if...** - You have been diagnosed with interstitial lung disease (ILD), such as idiopathic interstitial pneumonia, chronic hypersensitivity pneumonitis, or ILD related to connective tissue disease - You already use inhaled treprostinil - You have confirmed high blood pressure in your lungs (pulmonary hypertension), verified by a right heart catheterization - You are able to walk at least 100 meters in a 6-minute walk test **You may NOT be eligible if...** - Your pulmonary hypertension is caused by something other than lung disease (e.g., left-heart problems or blood clots) - You have had a flare of your lung disease in the last 28 days - You require very high levels of supplemental oxygen (more than 10 L/min at rest) - You have previously tried mosliciguat and did not tolerate it Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGinhaled mosliciguat

Dose level 1, 2, or 3 for inhalation

DEVICEDry Powder Inhaler

Dry powder inhaler for mosliciguat delivery


Locations(1)

Florida Lung, Asthma & Sleep Specialists/Clinical Research Specialists, LLC

Kissimmee, Florida, United States

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NCT07333183


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