Biomarker Approach to Screening for the Early Detection of HPV-related Oropharyngeal Cancer (BASH OPC)

This study is developing and testing blood-based biomarkers — measurable biological signals in the bloodstream — that could help detect HPV-related throat cancer (oropharyngeal cancer) earlier, before it becomes more advanced. **You may be eligible if...** - You are 18 years or older - You have been newly diagnosed with squamous cell cancer of the throat (oropharynx), stages I–IV, confirmed by biopsy - You have not yet received treatment (surgery, chemotherapy, radiation, or immunotherapy) in the past 4 weeks - OR you are a healthy person aged 35 or older with no history of head and neck cancer or HPV-related cancer who is willing to serve as a comparison participant **You may NOT be eligible if...** - You have already started cancer treatment - You have a previous history of head and neck cancer (for healthy participants) - You do not meet the study site's consent and enrollment requirements Talk to your doctor to see if this trial is right for you.