RecruitingPhase 3NCT05451004

SPECT-CT Guided ELEctive Contralateral Neck Treatment for Patients With Lateralized Oropharyngeal Cancer

SPECT-CT Guided ELEctive Contralateral Neck Treatment for Patients With Lateralized Oropharyngeal Cancer. A Phase III Randomized Controlled Trial

Sponsor

Canadian Cancer Trials Group

Enrollment

510 participants

Start Date

Feb 10, 2023

Study Type

INTERVENTIONAL

Conditions

Oropharyngeal Cancer

Summary

This study is being done to answer the following question: Is the chance of cancer spreading or returning the same if radiotherapy to the neck is guided, by using a special imaging study called lymph node mapping (lymphatic mapping) Single Photon Emission Computed Tomography (SPECT-CT), compared to the usual treatment when radiotherapy is given to both sides of the neck?

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study uses a special type of CT scan combined with nuclear medicine imaging (SPECT-CT) to guide radiation treatment decisions for head and neck cancers that occur on one side of the throat or mouth. It aims to determine whether imaging can help doctors decide which lymph nodes on the other (unaffected) side of the neck need to be treated with radiation. **You may be eligible if...** - You have been diagnosed with a head and neck cancer (such as tonsil or tongue base cancer) that is clearly on one side - Your doctor is planning radiation treatment - You are fit enough to undergo radiation therapy **You may NOT be eligible if...** - Your cancer has clearly spread to lymph nodes on both sides of the neck - You have already received radiation to the head and neck area - You cannot undergo the required imaging Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERLymphatic Mapping with SPECT-CT

Radiation: Ipsilateral Neck Radiotherapy and SPECT-CT Guided Contralateral Neck Radiotherapy

RADIATIONIpsilateral and Contralateral Neck

Radiotherapy

Locations(36)

City of Hope Corona

Corona, California, United States

City of Hope Comprehensive Cancer Center

Duarte, California, United States

City of Hope at Irvine Lennar

Irvine, California, United States

UM Sylvester Comprehensive Cancer Center at Coral Gables

Coral Gables, Florida, United States

Baptist MD Anderson Cancer Center

Jacksonville, Florida, United States

University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami, Florida, United States

Moffitt Cancer Center-International Plaza

Tampa, Florida, United States

Moffitt Cancer Center - McKinley Campus

Tampa, Florida, United States

Moffitt Cancer Center

Tampa, Florida, United States

Emory University Hospital Midtown

Atlanta, Georgia, United States

Northwestern University

Chicago, Illinois, United States

Northwestern Medicine Cancer Center Warrenville

Warrenville, Illinois, United States

The James Graham Brown Cancer Center at University of Louisville

Louisville, Kentucky, United States

University of Michigan Rogel Cancer Center

Ann Arbor, Michigan, United States

University of Michigan - Brighton Center for Specialty Care

Brighton, Michigan, United States

Henry Ford Hospital

Detroit, Michigan, United States

MU Health - University Hospital/Ellis Fischel Cancer Center

Columbia, Missouri, United States

UNC Lineberger Comprehensive Cancer Center

Chapel Hill, North Carolina, United States

Providence Portland Medical Center

Portland, Oregon, United States

MD Anderson in The Woodlands

Conroe, Texas, United States

M D Anderson Cancer Center

Houston, Texas, United States

MD Anderson West Houston

Houston, Texas, United States

MD Anderson League City

League City, Texas, United States

MD Anderson in Sugar Land

Sugar Land, Texas, United States

University of Vermont Medical Center

Burlington, Vermont, United States

University of Vermont and State Agricultural College

Burlington, Vermont, United States

BCCA-Vancouver Cancer Centre

Vancouver, British Columbia, Canada

CancerCare Manitoba

Winnipeg, Manitoba, Canada

Health Sciences North

Greater Sudbury, Ontario, Canada

Saint Joseph's Healthcare Charlton Campus

Hamilton, Ontario, Canada

Juravinski Cancer Centre at Hamilton Health Sciences

Hamilton, Ontario, Canada

Odette Cancer Centre- Sunnybrook Health Sciences Centre

Toronto, Ontario, Canada

University Health Network-Princess Margaret Hospital

Toronto, Ontario, Canada

CHUM - Centre Hospitalier de l'Universite de Montreal

Montreal, Quebec, Canada

Jewish General Hospital

Montreal, Quebec, Canada

Centre Hospitalier Universitaire de Sherbrooke-Fleurimont

Sherbrooke, Quebec, Canada

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

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NCT05451004

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