Comparative Study of New Classification and Traditional Classification of Radioactive Oropharyngeal Mucositis
A Comparative Study on the Evaluation Consistency Between the New Type and the Traditional Grade of Radioactive Oropharyngeal Mucositis and the Exploration of Blood Markers
Nanfang Hospital, Southern Medical University
264 participants
Sep 1, 2025
OBSERVATIONAL
Conditions
Summary
Radiation oropharyngeal mucositis is one of the most painful side effects of radiotherapy in patients with head and neck tumors. However, the traditional radioactive oropharyngeal mucositis grading system has the problem of poor evaluation consistency. To solve this problem, we innovatively classify radiation oropharyngeal mucositis into four types according to the four-stage histopathological changes of acute radiation injury: (1) congestive; (2) Scattered erosion type; (3) Fusion erosion type; (4) Ulcer type. We intend to conduct a multicenter observational cohort study to compare the consistency of different physicians in the assessment of radiation oropharyngeal mucositis with new and traditional classifications, and to explore changes in blood markers of different types of oropharyngeal mucositis using clinical residual blood samples.
Eligibility
Inclusion Criteria3
- Voluntarily sign informed consent;
- Age 18 or older on the date of signing the informed consent;
- Histologically confirmed head and neck tumor, radiotherapy or chemoradiotherapy.
Exclusion Criteria1
- They also have other uncontrolled serious medical conditions, such as unstable heart disease requiring treatment, poorly controlled diabetes (fasting blood glucose \> 1.5× the upper limit of normal), mental illness, and a history of severe allergies
Locations(4)
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NCT06307327