RecruitingNCT06309745

THERApy De-escalation for TESTicular Cancer

Sponsor

Queen Mary University of London

Enrollment

30 participants

Start Date

Jun 24, 2024

Study Type

OBSERVATIONAL

Conditions

Seminoma

Summary

THERATEST is looking to collect data from 30 patients actively receiving de-escalation treatments or other standard of care treatments in two UK hospitals. THERATEST is a feasibility study to determine whether patients are willing to be recruited, the impact of de-escalation treatments on patients' cancers and quality of life, whether we should proceed with these treatments in a larger study, and if so how the study should be conducted. A feasibility study prepares the ground for a larger study and improves the chances of the subsequent study producing valuable evidence, and helps to avoid wasting precious resources on larger trials that are unlikely to be informative. We hope that information from THERATEST will bridge the current knowledge gap and allow clinicians to design bigger trials to actively compare the different treatment strategies.

Eligibility

Sex: MALEMin Age: 16 Years

Plain Language Summary

Simplified for easier understanding

This study explores whether some men with stage II testicular seminoma (a type of testicular cancer that has spread to nearby lymph nodes) can be treated with less intensive therapy — specifically, a minimally invasive lymph node surgery (robotic retroperitoneal lymph node dissection) instead of radiation or full chemotherapy — in order to reduce long-term side effects. **You may be eligible if...** - You are male, 16 years or older - You have been diagnosed with testicular seminoma (confirmed by biopsy or removal of the testicle) - Your cancer is stage IIA (small lymph node involvement) or early stage IIB - Your tumor markers (AFP, hCG, LDH) are normal or only mildly elevated - You are in good physical health for surgery (BMI under 34, good heart/lung function) **You may NOT be eligible if...** - Your cancer has spread beyond the retroperitoneal lymph nodes - You have multiple affected lymph nodes or bilateral involvement - You have significant other medical conditions that make surgery risky Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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