Concentrated Bone Marrow Aspirate in Revision ACL Reconstruction
Multi-Center Pilot Study to Evaluate Concentrated Bone Marrow Aspirate (cBMA) as a Treatment to Modify Post-Traumatic Osteoarthritis (PTOA) Following Revision Anterior Cruciate Ligament Reconstruction (ACLR)
Hospital for Special Surgery, New York
40 participants
Jan 22, 2024
INTERVENTIONAL
Conditions
Summary
The goal of this pilot randomized clinical trial is to look into the efficacy of concentrated bone marrow aspirate (cBMA) in improving post traumatic osteoarthritis (PTOA) symptoms in patients undergoing revision anterior cruciate ligament reconstruction surgery. The main questions it aims to answer are whether clinical outcomes, such as pain, are improved in patients who get cBMA with surgery, if there is a change in circulating markers of inflammation and what part of the cellular and molecular composition of cBMA may explain its effects.
Eligibility
Plain Language Summary
Simplified for easier understanding
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Interventions
Intraoperatively, bone marrow will be harvested from the iliac crest with a commercial kit, it will then be prepared via centrifugation and an injection of the resulting concentrated product (cBMA) will be administered in the operative knee. cBMA is an autologous biologic product.
A 2 mm sham incision will be made in the anatomical site where bone marrow would be harvested.
This is the standard-of-care surgical procedure.
Locations(2)
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NCT06311513