Anterior Cruciate Ligament Injuries Clinical Trials

43 recruitingLast updated: June 18, 2026

There are 43 actively recruiting anterior cruciate ligament injuries clinical trials across 17 countries. Studies span Not Applicable, Phase 4, Early Phase 1, Phase 2, Phase 3. Top locations include Chapel Hill, North Carolina, United States, Ankara, Turkey (Türkiye), New York, New York, United States. Updated daily from ClinicalTrials.gov.


Anterior Cruciate Ligament Injuries Trials at a Glance

43 actively recruiting trials for anterior cruciate ligament injuries are listed on ClinicalTrialsFinder across 6 cities in 17 countries. The largest study group is Not Applicable with 28 trials, with the heaviest enrollment activity in Chapel Hill, Ankara, and New York. Lead sponsors running anterior cruciate ligament injuries studies include University of North Carolina, Chapel Hill, Hospital for Special Surgery, New York, and Chinese University of Hong Kong.

Browse anterior cruciate ligament injuries trials by phase

Treatments under study

About Anterior Cruciate Ligament Injuries Clinical Trials

Looking for clinical trials for Anterior Cruciate Ligament Injuries? There are currently 44 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Anterior Cruciate Ligament Injuries trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Anterior Cruciate Ligament Injuries clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 43 trials

Recruiting
Not Applicable

Quadriceps Tendon Versus Bone Patellar Tendon Bone Autograft ACL Reconstruction RCT

Orthopedic DisorderAnterior Cruciate Ligament Injuries
University of Alabama at Birmingham100 enrolled1 locationNCT05461326
Recruiting
Not Applicable

Gait Rehabilitation to Treat FastOA

Knee injuriesKnee OsteoarthritisOsteo Arthritis Knee+4 more
University of North Carolina, Chapel Hill70 enrolled1 locationNCT05848622
Recruiting
Not Applicable

Robotic Assistance for Tunnel Positioning in Anterior Cruciate Ligament Reconstruction

Anterior Cruciate Ligament Injuries
Centre Hospitalier Universitaire, Amiens30 enrolled1 locationNCT04183803
Recruiting
Not Applicable

Steps Towards Osteoarthritis Prevention

Anterior Cruciate Ligament Injuries
University of Georgia56 enrolled1 locationNCT06193343
Recruiting

Baseline ACL Injury Risk Screening and Normative Data

Musculoskeletal injuryAnterior Cruciate Ligament InjuriesACL Injury
Sanford Health5,000 enrolled1 locationNCT06635668
Recruiting

Clinical Outcomes of Arthroscopic Surgeries for Shoulder and Knee Sports Injuries

Anterior Cruciate Ligament InjuriesShoulder Dislocation or SubluxationPosterior Cruciate Ligament Tear+3 more
Second Affiliated Hospital, School of Medicine, Zhejiang University500 enrolled1 locationNCT07501013
Recruiting
Phase 4

Intraosseous Morphine Administration During Anterior Cruciate Ligament Reconstruction

Anterior cruciate ligament ruptureAnterior Cruciate Ligament InjuriesAnterior Cruciate Ligament tear
The Methodist Hospital Research Institute84 enrolled1 locationNCT06511232
Recruiting
Not Applicable

Bracing and Reconstruction of the Anterior Cruciate Ligament for Efficacy Trial

Anterior Cruciate Ligament Injuries
Wake Forest University Health Sciences96 enrolled1 locationNCT06942754
Recruiting
Not Applicable

Vibration on Patellofemoral Joint Pain After ACLR

Anterior cruciate ligament ruptureAnterior Cruciate Ligament InjuriesPatellofemoral Pain+1 more
Chinese University of Hong Kong50 enrolled1 locationNCT05501210
Recruiting
Phase 3

PRP in ACLR to Prevent PTOA

Post-traumatic OsteoarthritisAnterior Cruciate Ligament InjuriesPRP
Hospital for Special Surgery, New York56 enrolled1 locationNCT05412381
Recruiting
Early Phase 1

Biologic Therapy to Prevent Osteoarthritis After ACL Injury

Anterior Cruciate Ligament Injuries
University of California, Los Angeles32 enrolled1 locationNCT03968913
Recruiting

Magic Angle Direction Imaging (MADI) ACL Study

Anterior Cruciate Ligament InjuriesMeniscus Tear
Imperial College London20 enrolled2 locationsNCT07366619
Recruiting
Not Applicable

Investigation of the Effects of Proprioceptive Exercises After Anterior Cruciate Ligament Surgery

Anterior cruciate ligament ruptureAnterior Cruciate Ligament Injuries
Uskudar University50 enrolled1 locationNCT07333092
Recruiting
Not Applicable

Effect of Visual-Guided Balance Training on Knee Motor Function and Biomechanical Characteristics After ACL Reconstruction

Anterior Cruciate Ligament Injuries
Peking University Third Hospital45 enrolled1 locationNCT07306221
Recruiting
Not Applicable

Comparative Study of Functional Outcomes Between Peroneus Longus and Hamstring Tendon Autografts in Arthroscopic ACL Reconstruction

Anterior Cruciate Ligament Injuries
Khyber Medical University Peshawar64 enrolled1 locationNCT07346326
Recruiting
Not Applicable

The Impact of Blood Flow Restriction Training in Adolescents After ACL Reconstruction: A Randomized Controlled Trial

Knee injuriesQuadriceps Muscle AtrophyAnterior Cruciate Ligament Injuries
Connecticut Children's Medical Center40 enrolled1 locationNCT05754632
Recruiting
Not Applicable

Dynamic Muscular Electrical Stimulation Following Anterior Cruciate Ligament Reconstruction in Military Academy Cadets

Anterior Cruciate Ligament Injuries
Keller Army Community Hospital60 enrolled1 locationNCT06341868
Recruiting
Phase 4

Concentrated Bone Marrow Aspirate in Revision ACL Reconstruction

Anterior Cruciate Ligament InjuriesACL InjuryPost-Traumatic Osteoarthritis of Knee+1 more
Hospital for Special Surgery, New York40 enrolled2 locationsNCT06311513
Recruiting
Not Applicable

Graded Exposure and Mindfulness Meditation for Patients Post-ACL Reconstruction

Anterior Cruciate Ligament Injuries
University of North Carolina, Chapel Hill50 enrolled1 locationNCT05949177
Recruiting
Not Applicable

Comparison Between Combined ALLR With Single Bundle and Double Bundle Anterior Cruciate Ligament Reconstruction

Anterior Cruciate Ligament InjuriesAnterior cruciate ligament reconstruction
Chang Gung Memorial Hospital40 enrolled1 locationNCT06341192