Precision Adjuvant Therapy After Surgery for Hepatocellular Carcinoma

This study tests a personalized (precision) approach to therapy after surgical removal of hepatocellular carcinoma (liver cancer). It focuses specifically on patients whose tumor has a particular blood vessel growth pattern (called VETC) that makes the cancer more likely to return. The goal is to select the right follow-up treatment to reduce recurrence. **You may be eligible if...** - You are between 18 and 75 years old - You have been diagnosed with liver cancer (hepatocellular carcinoma) and have not had any prior treatment - Your liver function score (Child-Pugh) is 7 or below - You are in good general health (ECOG 0–1) - Your tumor tissue testing confirms the VETC vascular pattern by special staining (CD34 immunohistochemistry) **You may NOT be eligible if...** - You are pregnant or breastfeeding - You have active serious infections - You have had gastrointestinal bleeding within the past 4 weeks or are at high risk for it - You have significant absorption problems or chronic severe diarrhea Talk to your doctor to see if this trial is right for you.