RecruitingNot ApplicableNCT06312046

Motor-cognitive Performance in People With Multiple Sclerosis

Motor-cognitive Performance in People With Multiple Sclerosis - Brain Activity and Effects of Balance Exercise


Sponsor

Karolinska Institutet

Enrollment

90 participants

Start Date

Feb 26, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

Having a neurological disease such as multiple sclerosis (MS) leads to difficulties in balance and gait with or without concurrent performance of cognitive tasks, hindering activity performance and influencing the possibilities for an independent lifestyle. The investigators have adapted a previously developed balance training program to a highly challenging program specifically directed to MS (HiBalance-MS). This program was recently tested and found feasible in a pilot study. The investigators will now perform a randomized controlled trial in people with MS, in order to determine the effects of the program. The hypothesis is that progressively challenging balance exercise programs that are specific to the balance control domains affected by MS will be effective to improve balance control, walking, motor-cognitive performance, activity performance and health related quality of life.


Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study evaluates how people with multiple sclerosis (MS) perform on tasks that require both movement and thinking at the same time — called motor-cognitive dual tasks. Examples include walking while counting or carrying on a conversation. These combined tasks are often harder for people with MS and can affect their safety and independence. **You may be eligible if...** - You have been diagnosed with multiple sclerosis (MS) according to established criteria - You are between 18 and 65 years old - Your disability level is in the mild to moderate range (EDSS score 2.0 to 5.5) - You can walk 100 meters without assistance - Your balance shows some room for improvement (Mini-BESTest score below 25) **You may NOT be eligible if...** - You have significant cognitive impairment (MoCA score below 21) - You have other conditions that substantially affect your balance - You have had an MS relapse or changed your MS medication in the past 8 weeks Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERHiBalance-MS

See arm description for intervention group.


Locations(1)

Karolinska Institutet

Stockholm, Stockholm County, Sweden

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NCT06312046


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