Cancer Related Major Depression Treated With a Single Dose of Psilocybin

This study tests whether a single dose of psilocybin — the active compound found in "magic mushrooms" — can treat major depression in people who are living with cancer. It is a carefully supervised clinical trial conducted in Sweden that monitors participants closely before and after the treatment session. **You may be eligible if...** - You are between 20 and 80 years old - You read, speak, and understand Swedish - You have been diagnosed with a malignant cancer (any type from C00 to C97) - You have a diagnosis of major depressive disorder related to your cancer - You are at least 1 month past your cancer diagnosis - Women of childbearing potential must use effective contraception during the study **You may NOT be eligible if...** - You have a personal or family history of psychosis, schizophrenia, or bipolar disorder - You have a cardiovascular condition that makes psilocybin unsafe - You are taking certain medications (such as SSRIs or lithium) that interact with psilocybin - You are pregnant, breastfeeding, or planning pregnancy Talk to your doctor to see if this trial is right for you.