RecruitingNCT07422844

Dynamic Network Response to TMS Treatment

Dynamic Network Changes During Transcranial Magnetic Stimulation Therapy in Depression

Sponsor

Goethe University

Enrollment

100 participants

Start Date

Nov 24, 2025

Study Type

OBSERVATIONAL

Conditions

MDD

Summary

This project aims to investigate whether symptom and brain networks and TMS stimulation sites can predict the response to TMS treatment of a transdiagnostic patient group with depressive syndrome. The TMS treatment is no intervention study - the investigators aim to observe patients who receive TMS as part of their psychiatric treatment. Additionally, the investigators aim to investigate exploratively how symptoms change over the course of treatment with TMS, that is, which symptoms respond first to treatment. Patients participate in a separate study first (DYNAMIC Central Project, registered with the German Clinical Trials Register: DRKS00038256), where MRI data is acquired. Within this project the symptomatology before, during and after the TMS-treatment are observed.

Eligibility

Min Age: 18 YearsMax Age: 70 Years

Inclusion Criteria3

Patients who are treated with TMS as an antidepressant will be recruited for study participation. The TMS treatment is carried out regardless of study participation.
Men and women will be included in a balanced ratio.
German language skills are required to ensure that questionnaires, interviews, and instructions are correctly understood, processed and answered.

Exclusion Criteria4

Patients younger than 18 or older than 70 will be excluded
Participants who did not participate in the DYNAMIC central project (German Clinical Trials Register DRKS00038256) will be excluded.
Patients who are pregnant will not be included in the study.
As we use app-based questionnaires, we cannot include participants without internet-enabled devices in the study.