RecruitingNCT07422844

Dynamic Network Response to TMS Treatment

Dynamic Network Changes During Transcranial Magnetic Stimulation Therapy in Depression

Sponsor

Goethe University

Enrollment

100 participants

Start Date

Nov 24, 2025

Study Type

OBSERVATIONAL

Conditions

MDD

Summary

This project aims to investigate whether symptom and brain networks and TMS stimulation sites can predict the response to TMS treatment of a transdiagnostic patient group with depressive syndrome. The TMS treatment is no intervention study - the investigators aim to observe patients who receive TMS as part of their psychiatric treatment. Additionally, the investigators aim to investigate exploratively how symptoms change over the course of treatment with TMS, that is, which symptoms respond first to treatment. Patients participate in a separate study first (DYNAMIC Central Project, registered with the German Clinical Trials Register: DRKS00038256), where MRI data is acquired. Within this project the symptomatology before, during and after the TMS-treatment are observed.

Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at how the brain's networks respond to a type of non-invasive brain stimulation called TMS (transcranial magnetic stimulation), which is already being used as a treatment for depression. Researchers want to understand what happens inside the brain during and after this treatment. **You may be eligible if...** - You are between 18 and 70 years old - You are already receiving TMS treatment for depression as part of your regular care - You speak German fluently - You are already enrolled in the DYNAMIC central research project - You have a smartphone or internet-connected device **You may NOT be eligible if...** - You are younger than 18 or older than 70 - You have a neurological condition (such as epilepsy or a brain injury) - You are pregnant - You do not speak German - You are not part of the DYNAMIC central project Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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