NUTRIMOOD-Inflammation and Depressive Comorbidity in Obesity: Modulation by Omega-3 Polyunsaturated Fatty Acids Status

This study (NUTRIMOOD) is investigating how omega-3 fatty acid levels in the body relate to depression and inflammation in people who are obese. Researchers want to understand whether low omega-3 levels contribute to both depression and the chronic low-grade inflammation seen in obesity. **You may be eligible if...** - You have been diagnosed with major depressive disorder - You are not currently taking antidepressant medications **You may NOT be eligible if...** - You have schizophrenia or a history of mania (bipolar) - You have obsessive-compulsive disorder or post-traumatic stress disorder - You have an anxiety disorder (other than social phobia or generalized anxiety, which may be okay) - You have an alcohol or drug use disorder (smoking is acceptable) - You have active thoughts of suicide - You have a serious medical or neurological condition, especially if it requires corticosteroids, anti-inflammatory medications, immunosuppressants, or long-term thyroid hormone treatment Talk to your doctor to see if this trial is right for you.