Non-invasive Spinal, Cortical, and Sensorimotor Biomarkers in Motor Neurone Disease

This study measures nerve and brain activity in people with motor neuron diseases — conditions that cause the nerve cells controlling muscles to break down — using non-invasive sensors on the skin. The goal is to identify biological markers (biomarkers) that can track disease progression. **You may be eligible if...** - You have a diagnosis of ALS, primary lateral sclerosis (PLS), progressive muscular atrophy (PMA), spinal muscular atrophy (SMA), post-polio syndrome, or multiple sclerosis (MS) - You are able to give informed consent - OR you are a healthy volunteer matched in age and gender to a patient group with intact physical ability to participate **You may NOT be eligible if...** - You are a healthy volunteer with a history of neuromuscular, neurological, or active psychiatric disease - You have active psychiatric disease - You have severe neuropathy from poorly controlled diabetes or other causes - You have allergies to recording equipment or gels used in the study Talk to your doctor to see if this trial is right for you.