Non-invasive Spinal, Cortical, and Sensorimotor Biomarkers in Motor Neurone Disease
Developing Novel Non-invasive Electrophysiological Biomarkers of Dysfunction in Spinal and Cortical Pathways and Sensorimotor Impairments in Motor Neurone Disease
University of Dublin, Trinity College
240 participants
Jun 15, 2023
OBSERVATIONAL
Conditions
Summary
Substantial variability exists in the onset, and rate of degeneration across individuals with Motor Neurone Disease (MND) or Amyotrophic Lateral Sclerosis (ALS). This variability requires biomarkers that accurately classify and reliably track clinical subtypes as the disease progresses. Degeneration occurs in the brain and spinal cord, however, non-invasive diagnosis of spinal cord function remains highly challenging due to its unique alignment in spine. Disruption of complex spinal and cortical circuits that transmit and process neural signals for position sense and movement has not been adequately captured in the neurophysiological profiling of ALS patients. The overarching aim of this study is to reveal and quantify the extent of change in the sensorimotor integration and its potential contribution to network disruption in ALS.
Eligibility
Inclusion Criteria7
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- Healthy Volunteers:
- age and gender matched to patient groups
- intact physical ability to take part in the experiment.
- Patients:
- Diagnosis of ALS, PLS, PMA, SMA, Polio or MS
- capable of providing informed consent.
Exclusion Criteria9
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- Healthy Controls:
- History of neuromuscular
- neurological or active psychiatric disease disease
- history of reaction or allergy to recording environments, equipment and the recording gels.
- Patients:
- presence of active psychiatric disease
- any medical condition associated with severe neuropathy (e.g. poorly controlled diabetes).
- History of reaction or allergy to recording environments, equipment and the recording gels.
Interventions
Noninvasive 232 Channel Electrode Electrophysiological signals (EEG-ECG-EMG-EXG) will be recorded from electrodes placed in a montage over the scalp, neck,and upper back along with muscles located on the hand. These signals will be recorded while resting or performing voluntary task. Other Intervention: The 232 electrode noninvasive electrophysiological data will be recorded in response to non-invasive peripheral nerve stimulation or vibration induced stimulation. These sessions are designed to engage specific cortical motor networks of interest for evaluating sensorimotor networks. (Cognitive, behavioural, motor, spinal, and sensory)
Locations(1)
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NCT06320444