PCOS Immune Function Predicts Metformin Efficacy

This study investigates whether differences in immune function can predict how well the diabetes medication metformin works in women with polycystic ovary syndrome (PCOS) — a hormonal condition that affects periods, fertility, and metabolism. Researchers hope to use immune markers to better personalize treatment for PCOS. **You may be eligible if...** - You are between 18 and 45 years old - You have been diagnosed with PCOS using standard diagnostic criteria (Rotterdam 2003) **You may NOT be eligible if...** - You are pregnant - You have thyroid problems (over- or underactive thyroid) - You have serious liver or kidney disease - You have cancer - You have severe blood conditions (severe anemia, low white cell count) - You have type 1 diabetes, genetic diabetes, or another type of secondary diabetes - You have a mental illness or intellectual disability - You have taken PCOS medications in the last 3 months - You have a long history of hormone therapy - You are currently participating in another clinical trial Talk to your doctor to see if this trial is right for you.