Metformin Clinical Trials

11 recruiting

Metformin Trials at a Glance

12 actively recruiting trials for metformin are listed on ClinicalTrialsFinder across 6 cities in 6 countries. The largest study group is Phase 2 with 4 trials, with the heaviest enrollment activity in Beijing, Aurora, and Baltimore. Lead sponsors running metformin studies include Assistance Publique - Hôpitaux de Paris, Centre Hospitalier de Saint-Denis, and Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.

Browse metformin trials by phase

Treatments under study

About Metformin Clinical Trials

Looking for clinical trials for Metformin? There are currently 11 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Metformin trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Metformin clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 112 of 12 trials

Recruiting
Phase 4

Investigation of Metformin in Pre-Diabetes on Atherosclerotic Cardiovascular OuTcomes

AtherosclerosisMetforminPrediabetic State
VA Office of Research and Development7,410 enrolled40 locationsNCT02915198
Recruiting
Phase 3

Evaluation of the Efficacy and Safety of Metformin in the Myotonic Dystrophy Type 1 (Steinert's Disease)

MetforminMyotonic Dystrophy 1Steinert's Disease
Assistance Publique - Hôpitaux de Paris142 enrolled1 locationNCT05532813
Recruiting

Clinical and Biological Signs of Dapagliflozin Overdose in ICU Patients With Metformin Poisoning

MetforminDiabetic KetoacidosisDrug Overdose+3 more
Centre Hospitalier de Saint-Denis50 enrolled1 locationNCT07193069
Recruiting
Phase 2

Phase 2, Open-label, Single-arm Study on the Use of Metformin as Adjunctive Therapy in High-grade Glioma

Glioblastoma, IDH-wildtypeMetforminMalignancies
University of Milano Bicocca25 enrolled1 locationNCT05929495
Recruiting
Phase 2

Pilot Study on Evaluating the Geroprotective Effect of Metformin

AgingMetformin
Xuanwu Hospital, Beijing130 enrolled1 locationNCT06459310
Recruiting
Phase 4

Metformin in Children With Fragile X Syndrome

Fragile X SyndromeMetformin
Children's Hospital of Fudan University20 enrolled1 locationNCT05120505
Recruiting
Phase 2

Chemoradiotherapy With or Without Metformin in Locally Advanced Cervical Cancer

Cervical CancerPET/CTRadiotherapy+2 more
Peking Union Medical College Hospital51 enrolled1 locationNCT06353061
Recruiting

Comparative Analysis of Cost-effectiveness Between Sulfonylureas and DPP4 Inhibitors in Combination With Metformin in Treatment of Type 2 Diabetic Patients : A Retrospective, Observational Study.

Type 2 Diabetes Mellitus (T2DM), Cost-effectiveness, Sulfonylureas, DPP4 Inhibitors, Metformin
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh200 enrolled1 locationNCT06570980
Recruiting
Not Applicable

Effect of Metformin on Healthy Live Birth in Women With Prediabetes

PrediabetesMetforminIn-Vitro Fertilization
Shandong University988 enrolled1 locationNCT06064669
Recruiting
Not Applicable

PCOS Immune Function Predicts Metformin Efficacy

Polycystic Ovary SyndromeImmune FunctionMetformin
Shanghai 10th People's Hospital100 enrolled1 locationNCT06325956
Recruiting
Phase 3

Extending Time Without Diabetes After Bariatric Surgery: a Trial Comparing the Metformin Addition or Not to Standard Care

Bariatric SurgeryDiabetesMetformin
Assistance Publique - Hôpitaux de Paris126 enrolled16 locationsNCT04581447
Recruiting
Phase 2

Effect of Tofogliflozin on UACR Compared to Metformin Hydrochloride in Diabetic Kidney Disease (TRUTH-DKD)

MetforminT2DM (Type 2 Diabetes Mellitus)SGLT2-Inhibitors
Shinshu University120 enrolled1 locationNCT05469659