Anesthesia and Non-small Cell Lung Cancer Recurrence
Recurrence Free Survival After Curative Resection of Non-small Cell Lung Cancer Between Inhalational Gas Anesthesia and Propofol-based Total IntraVenous Anesthesia: a Multicenter, Randomized, Clinical Trial
Samsung Medical Center
5,384 participants
Aug 5, 2024
INTERVENTIONAL
Conditions
Summary
There has been ongoing debate about the relationship between cancer recurrence and anesthetic management. Therefore, the investigators will test the hypothesis that the recurrence free survival (RFS) after curative resection of NSCLC is higher in patient who received total intravenous anesthesia (TIVA) than volatile anesthetics in this multi-center randomized trials.
Eligibility
Inclusion Criteria3
- American Society of Anesthesiologists physical status (ASA) Ⅰ-Ⅲ
- The Eastern Cooperative Oncology Group (ECOG) performance status 0-2
- Lung resection surgery (segmentectomy, lobectomy, bilobectomy, pneumonectomy; video-assisted, robot-assisted, or open) with curative intent for NSCLC (clinical Tumor, Node, Metastasis (TNM) stage Ⅰ- ⅢA).
Exclusion Criteria12
- Distant metastasis or malignant tumor in other organs that according to the attending surgeon is not in long-term remission
- Severe neurologic conditions
- Severe hepatic disease (Child-Pugh classification C)
- Renal failure requiring renal replacement therapy
- History of anesthesia and/or surgery within 1 yr
- Previous surgery due to lung cancer (except diagnostic biopsies)
- Contraindications to any study medication (history of allergy, hypersensitivity reaction, or any other contraindication)
- Planned joint extrapulmonary procedure
- Surgery under cardiopulmonary bypass or extracorporeal membrane oxygenation
- Postoperative sedation
- Pregnancy, or lactation
- Patient refusal.
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Interventions
Propofol will be used for the induction and maintenance of general anesthesia.
Inhaled anesthetics will be used for the maintenance of general anesthesia.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06330038