Quetiapine to Reduce Post Concussive Syndrome After Mild Traumatic Brain Injury (mTBI)

This study is testing whether quetiapine — a medication used for psychiatric conditions — can help veterans who continue to experience persistent symptoms after a mild traumatic brain injury (concussion). These ongoing symptoms, called post-concussive syndrome, can include memory problems, sleep issues, anxiety, and irritability. **You may be eligible if...** - You are a veteran between ages 18 and 65 - You have a confirmed diagnosis of mild traumatic brain injury (mTBI) and ongoing post-concussive symptoms, at least 6 months after the injury - You are currently on at least three stable psychiatric or neurological medications - You have significant PTSD-related symptoms (PCL-5 score of 25 or higher) **You may NOT be eligible if...** - You have a moderate or severe TBI, or major dementia - You have a known allergy or significant adverse reaction to quetiapine - You are pregnant, breastfeeding, or planning pregnancy - You have certain serious heart, liver, or metabolic conditions that would make quetiapine unsafe Talk to your doctor to see if this trial is right for you.