RecruitingNot ApplicableNCT06335771

Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity

Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity-Associated Diseases

Sponsor

Bettina Mittendorfer

Enrollment

60 participants

Start Date

Aug 1, 2024

Study Type

INTERVENTIONAL

Conditions

Obesity Healthy Diabetes Type 2 Nonalcoholic Fatty Liver

Summary

The goal of this study is to evaluate the role of transcription factor EB (TFEB) in adipose (fat) tissue macrophages (ATM) in regulating adipose tissue and systemic metabolic function in obesity. The investigators will assess the differences in ATM lipid metabolism in people with metabolically abnormal obesity and lean individuals. Both groups will have: * screening visit * imaging (body composition testing - dual-energy x-ray absorptiometry (DEXA) scans, magnetic resonance imaging \[MRI\] and magnetic resonance spectroscopy \[MRS\] scans) * Overnight visit with intravenous infusion (IV), muscle, and fat tissue biopsies Participants with obesity will complete meetings with study team members for a weight loss intervention to achieve a 10% body weight loss.

Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This research study is investigating how fat (lipid) processing inside immune cells called macrophages relates to obesity and metabolic disease. Researchers are looking at fat tissue samples to understand what goes wrong at a cellular level in people who are obese, which could point toward new treatments. **You may be eligible if...** - You are between 18 and 70 years old - You are weight-stable and have been relatively sedentary before enrolling - You do not smoke or drink excessive alcohol - You fit one of the study groups: healthy lean, metabolically healthy obesity, or obesity with type 2 diabetes **You may NOT be eligible if...** - You are pregnant or breastfeeding - You have serious organ disease (such as advanced kidney disease or cancer) - You are taking certain medications that affect sugar or fat metabolism (beyond those allowed for the diabetes group) - You use tobacco products Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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