Lumateperone for the Improvement of Apathy in Patients With Psychotic Symptoms.

This study is testing lumateperone — an atypical antipsychotic medication — to see whether it can reduce apathy (a lack of motivation and emotional engagement) in people who have schizophrenia or a related psychotic disorder. Apathy is a common and debilitating symptom that is often undertreated. **You may be eligible if...** - You are 18–65 years old - You have been diagnosed with schizophrenia, schizoaffective disorder, or a related psychotic disorder - You scored above a certain threshold on apathy and symptom rating scales at screening - You have been on a stable treatment regimen for at least 30 days - You are not pregnant or breastfeeding (if applicable) **You may NOT be eligible if...** - Your symptoms are unstable or you recently changed medications - You have certain medical conditions that would make participation unsafe - You are unable to comply with all required assessments Talk to your doctor to see if this trial is right for you.