RecruitingNCT06342440

Early Detection of Advanced Adenomas and Colorectal Cancer

A Liquid Biopsy Assay For The Non-Invasive Early Detection of Advanced Adenomas and Colorectal Cancer


Sponsor

City of Hope Medical Center

Enrollment

2,000 participants

Start Date

Mar 15, 2020

Study Type

OBSERVATIONAL

Conditions

Summary

This study aims to develop a highly sensitive, specific, and cost-effective blood assay for early detection of colorectal adenomas and cancer, using advanced machine learning and state-of-the-art biological analyses.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is developing a blood test to detect advanced precancerous polyps (adenomas) and colorectal cancer earlier. Participants provide blood samples around the time of their colonoscopy so researchers can compare blood test results with what was actually found in the colon. **You may be eligible if...** - You are scheduled for or have recently had a colonoscopy - At least one blood sample was drawn before any curative treatment began - You have received standard diagnostic procedures as per local medical guidelines **You may NOT be eligible if...** - You have a hereditary colorectal cancer syndrome (such as Lynch syndrome) - You have inflammatory bowel disease - You have not provided written informed consent Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTDENEB

A panel of circulating microRNA, whose expression level is tested in cell-free and exosome-derived samples.


Locations(6)

City of Hope Medical Center

Monrovia, California, United States

University of California San Diego

San Diego, California, United States

The First Affiliated Hospital of Dalian Medical University

Dalian, China

IRCCS San Raffaele

Milan, Italy

Mie University

Mie, Japan

Barcelona University

Barcelona, Spain

View Full Details on ClinicalTrials.gov

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NCT06342440


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