RecruitingNCT06342440

Early Detection of Advanced Adenomas and Colorectal Cancer

A Liquid Biopsy Assay For The Non-Invasive Early Detection of Advanced Adenomas and Colorectal Cancer

Sponsor

City of Hope Medical Center

Enrollment

2,000 participants

Start Date

Mar 15, 2020

Study Type

OBSERVATIONAL

Conditions

Colorectal, Cancer Colorectal Neoplasms Colorectal Adenocarcinoma Colorectal Neoplasms Malignant Colorectal Cancer Stage III Colorectal Polyp Colorectal Cancer Stage II Colorectal Cancer Stage IV Colorectal Adenomatous Polyp Colorectal Disorders Colorectal Cancer Stage I Colorectal Dysplasia Colorectal Serrated Adenocarcinoma Colorectal Adenoma With Severe Dysplasia Colorectal Adenoma With Mild Dysplasia Colorectal Adenoma With Moderate Dysplasia Colorectal Adenoma and Carcinoma 1 Colorectal Adenocarcinoma Metastatic in the Liver

Summary

This study aims to develop a highly sensitive, specific, and cost-effective blood assay for early detection of colorectal adenomas and cancer, using advanced machine learning and state-of-the-art biological analyses.

Eligibility

Min Age: 18 Years

Inclusion Criteria3

All individuals included in the study need to have had a colonoscopy at the time of blood sampling.
Received standard diagnostic and staging (as necessary) procedures as per local guidelines, and at least one sample was drawn before receiving any curative-intent treatment.
Received standard pathological and endoscopic diagnosis and assessment for cohort assignment.