Safety and Efficacy of Endobronchial Valve for Bronchoscopic Lung Volume Reduction Surgery: a Prospective Pilot Study

This study tests the safety and effectiveness of a bronchoscopic procedure — where small valves are placed in the airways using a flexible camera — to reduce the size of over-inflated, damaged lung areas in people with severe COPD (chronic obstructive pulmonary disease). **You may be eligible if...** - You have been diagnosed with COPD - You are between 40 and 85 years old - Your lung function tests show severe airflow limitation (FEV1 between 15–45% of expected) - You have stopped smoking for at least 4 months - You can walk between 100–500 meters in a 6-minute walking test after rehabilitation **You may NOT be eligible if...** - You are pregnant or breastfeeding - Your carbon dioxide levels are too high or oxygen levels too low on blood gas testing - You have significant bronchiectasis or active lung infection - You have been hospitalized for a lung problem in the past 3 months - You have certain heart conditions Talk to your doctor to see if this trial is right for you.