Emphysema Clinical Trials

39 recruitingLast updated: June 17, 2026

There are 39 actively recruiting emphysema clinical trials across 20 countries. Studies span Not Applicable, Phase 2, Early Phase 1, Phase 1. Top locations include Boston, Massachusetts, United States, Philadelphia, Pennsylvania, United States, Chicago, Illinois, United States. Updated daily from ClinicalTrials.gov.


Emphysema Trials at a Glance

39 actively recruiting trials for emphysema are listed on ClinicalTrialsFinder across 6 cities in 20 countries. The largest study group is Not Applicable with 16 trials, with the heaviest enrollment activity in Boston, Philadelphia, and Chicago. Lead sponsors running emphysema studies include Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Beth Israel Deaconess Medical Center, and McMaster University.

Browse emphysema trials by phase

Treatments under study

About Emphysema Clinical Trials

Looking for clinical trials for Emphysema? There are currently 31 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Emphysema trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Emphysema clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 39 trials

Recruiting
Not Applicable

A Multi Center Study Testing a New Implant for Adults With Severe Emphysema

COPDEmphysemaEmphysema or COPD
Pulmair Medical, Inc.60 enrolled3 locationsNCT07119229
Recruiting
Not Applicable

A Trial of the Implantable Artificial Bronchus 50 Flex in Patients With Severe Emphysema

COPDEmphysema
Pulmair Medical, Inc.20 enrolled2 locationsNCT07086339
Recruiting
Not Applicable

Ultrasound and Respiratory Physiological Signals in Lung Diseases

UltrasoundChronic Obstructive Pulmonary DiseaseInterstitial Lung Disease+5 more
Fondazione Policlinico Universitario Agostino Gemelli IRCCS25 enrolled1 locationNCT06068647
Recruiting
Not Applicable

Clinical-ultrasonographic Assessment of Pulmonary Emphysema

EmphysemaPulmonary Emphysema
Fondazione Policlinico Universitario Agostino Gemelli IRCCS1,628 enrolled4 locationsNCT06533371
Recruiting

Analysing Peripheral Skeletal Muscle Function Before and After Endobronchial Valve Treatment

Emphysema
University Medical Center Groningen15 enrolled1 locationNCT06025500
Recruiting

STRIVE Post-Market Registry Study

Emphysema
Olympus Corporation of the Americas150 enrolled14 locationsNCT04302272
Recruiting
Not Applicable

Bronchoscopic RElease of Air Trapped in Hyperinflated Emphysematous Lung - Study 3

COPDEmphysema
Apreo Health, Inc.250 enrolled22 locationsNCT06891755
Recruiting
Not Applicable

Inter-lobar Fissure Completion in Patients With Failed Bronchoscopic Lung Volume Reduction

Emphysema or COPD
Beth Israel Deaconess Medical Center20 enrolled1 locationNCT05257681
Recruiting
Not Applicable

Combined Zephyr Valve System With Inter-lobar Fissure Completion for Lung Volume Reduction in Emphysema

Emphysema or COPD
Beth Israel Deaconess Medical Center20 enrolled1 locationNCT04801108
Recruiting
Not Applicable

An Evaluation of the AeriSeal System for CONVERTing Collateral Ventilation Status in Patients With Severe Emphysema

Emphysema or COPDEmphysema, Pulmonary
Pulmonx Corporation200 enrolled36 locationsNCT06035120
Recruiting

PiMZ Longitudinal Cohort (PiMZ Logic)

Alpha 1-Antitrypsin DeficiencyEmphysema or COPD
Columbia University80 enrolled5 locationsNCT06505603
Recruiting
Phase 1Phase 2

Lung and Bone Marrow Transplantation for Lung and Bone Marrow Failure

Idiopathic Pulmonary FibrosisEmphysema or COPD
Paul Szabolcs8 enrolled2 locationsNCT03500731
Recruiting
Not Applicable

Implementation of a Sarcopenia Clinic to Diagnose and Treat Skeletal Muscle Loss Due to COPD

SarcopeniaCOPDEmphysema
The Cleveland Clinic80 enrolled1 locationNCT07059637
Recruiting
Phase 2

Long-term, Open-label Study of SAR447537 (INBRX-101) in Adults With Alpha-1 Antitrypsin Deficiency Emphysema

EmphysemaAlpha 1-Antitrypsin Deficiency
Sanofi185 enrolled40 locationsNCT05897424
Recruiting

Emphysema Research Registry and Biosample Repository

Chronic Obstructive Pulmonary DiseaseEmphysemaChronic Bronchitis
University of Pittsburgh3,000 enrolled1 locationNCT00307281
Recruiting
Not Applicable

A Multi-center RCT to Evaluate Subsegmental BTVA Treatment for Severe Emphysema

Severe Emphysema
Shanghai Chest Hospital100 enrolled9 locationsNCT06152107
Recruiting
Not Applicable

BENTO - Bronchoscopic Lung Volume Reduction in Severe Emphysema Using Thermoablation

Emphysema or Chronic Obstructive Pulmonary Disease
IHF GmbH - Institut für Herzinfarktforschung224 enrolled12 locationsNCT05717192
Recruiting

Exploring Novel Biomarkers for Emphysema Detection

COPDEmphysema
Maastricht University200 enrolled2 locationsNCT05825261
Recruiting

Identification of Multiple Pulmonary Diseases Using Volatile Organic Compounds Biomarkers in Human Exhaled Breath

Lung CancerLung InfectionCOPD+13 more
ChromX Health10,000 enrolled1 locationNCT06528418
Recruiting
Not Applicable

Safety and Efficacy of Endobronchial Valve for Bronchoscopic Lung Volume Reduction Surgery: a Prospective Pilot Study

Chronic Obstructive Pulmonary DiseaseEmphysema
China-Japan Friendship Hospital10 enrolled1 locationNCT06349174