RecruitingNCT06353607

Genetic Architecture of Acute Aortic Syndromes and Aortic Aneurysm.

Sponsor

University Hospital, Basel, Switzerland

Enrollment

730 participants

Start Date

Apr 8, 2024

Study Type

OBSERVATIONAL

Conditions

Thoracic Aortic Aneurysm Acute Aortic Dissection

Summary

The aim of this study is to explore the genetic information associated with the development of TAA and aAD in individuals without history or syndromic features (Marfan syndrome, Ehlers-Danlos syndrome, Turner syndrome etc.) for aortic disease. For this purpose, whole genome sequencing will be performed in patients with documented aortic aneurysm or/and aortic dissection.

Eligibility

Min Age: 18 Years

Inclusion Criteria2

All adult patients \> 18 years who underwent surgery for aAD or TAA intervention at the University Hospital Basel, starting in 2015.
All patients who will undergo surgery for aAD or TAA at the University Hospital Basel, beginning in 2024.

Exclusion Criteria2

Patients will be excluded if they are not able or not willing to provide informed consent.
Patients with diagnosed heritable vascular disorders, such as Marfan syndrome, Turner Syndrome, Loeyes Dietz and Ehlers-Danlos syndrome.

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