Psilocybin in Chronic Low Back Pain and Depression

This study tests whether psilocybin — the active compound in "magic mushrooms" — can help people who suffer from both chronic low back pain and depression. Researchers believe psilocybin may reset how the brain processes pain and mood, potentially offering relief for both conditions at once. **You may be eligible if...** - You are between 21 and 80 years old - You have had low back pain on most days for at least 6 months - You have at least moderate depression symptoms (score of 17 or higher on a standard scale) - You are fluent in English with at least a high school education - You agree to avoid other mind-altering substances on the day before and day of the study drug sessions - Your current therapy (such as antidepressants or talk therapy) has been stable for at least 2 months **You may NOT be eligible if...** - You are at high risk for suicidal behavior - You have a personal or family history of psychosis (schizophrenia) - You have a history of bipolar disorder with mania or certain other serious mental health conditions - You use illegal stimulants or have a substance use disorder - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.