Chronic Low-back Pain Clinical Trials

71 recruitingLast updated: June 17, 2026

There are 71 actively recruiting chronic low-back pain clinical trials across 27 countries. Studies span Not Applicable, Phase 2, Phase 1. Top locations include Baltimore, Maryland, United States, Orlando, Florida, United States, Boston, Massachusetts, United States. Updated daily from ClinicalTrials.gov.


Chronic Low-back Pain Trials at a Glance

71 actively recruiting trials for chronic low-back pain are listed on ClinicalTrialsFinder across 6 cities in 27 countries. The largest study group is Not Applicable with 49 trials, with the heaviest enrollment activity in Baltimore, Orlando, and Boston. Lead sponsors running chronic low-back pain studies include Johns Hopkins University, University of California, Los Angeles, and Boston Scientific Corporation.

Browse chronic low-back pain trials by phase

Treatments under study

About Chronic Low-back Pain Clinical Trials

Looking for clinical trials for Chronic Low-back Pain? There are currently 71 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Chronic Low-back Pain trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Chronic Low-back Pain clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 71 trials

Recruiting

Intracept Minimally-invasive PROcedure for VErtebrogenic Back Pain

Chronic Low-back PainVertebrogenic Pain Syndrome
Boston Scientific Corporation1,500 enrolled18 locationsNCT06827262
Recruiting
Not Applicable

Does the Therapist's Assessment of Movement Control in Low Back Pain Patients Correspond to an Objective Kinematic Modification

Chronic Low-back Pain
University Hospital, Brest50 enrolled1 locationNCT05511012
Recruiting
Not Applicable

Improving Health for Patients With Chronic Low Back Pain in Rural Communities Through Telerehabilitation

Chronic Low-back Pain
Johns Hopkins University434 enrolled2 locationsNCT06471920
Recruiting
Not Applicable

Managing Pain Using Optimized Sequences by Adjusting Parameters With Independent Current Control

Chronic leg painLeg painChronic Low-back Pain+3 more
Boston Scientific Corporation70 enrolled7 locationsNCT07190807
Recruiting
Not Applicable

Clinician Satisfaction With the VERABAND™

Chronic Low-back Pain
University of Michigan360 enrolled3 locationsNCT06080464
Recruiting
Not Applicable

"Lumbar Operatively Inserted PerQdisc Artificial Implant Following Nulcectomy" (LOPAIN2)

Chronic Low-back PainDegenerative Disc Disease
Spinal Stabilization Technologies72 enrolled10 locationsNCT05508360
Recruiting
Not Applicable

Detection of EEG-Based Biomarkers of Chronic Low Back Pain

HealthyChronic Low-back Pain
Stanford University130 enrolled1 locationNCT06025201
Recruiting
Not Applicable

Effectiveness of Thoracolumbar Fascia Mobilization and Ultrasound-Guided 5% Dextrose Injection in Chronic Low Back Pain

Chronic Low-back Pain
Ankara City Hospital Bilkent75 enrolled1 locationNCT07241559
Recruiting
Not Applicable

Telerehabilitation for Patients With Chronic Low Back Pain (TeleBACK Clinical Trial)

Chronic Low-back Pain
Johns Hopkins University1,000 enrolled3 locationsNCT06821607
Recruiting
Not Applicable

Implementation of the Specific Treatment Of Problems of the Spine Approach in Bangladesh

Chronic Low-back Pain
Mohammad Ali154 enrolled1 locationNCT05880212
Recruiting
Not Applicable

Sequential and Comparative Evaluation of Pain Treatment Effectiveness Response

Chronic Low-back Pain
VA Office of Research and Development2,529 enrolled19 locationsNCT04142177
Recruiting
Not Applicable

Virtual Reality-Based Rehabilitation Versus Conventional Therapy in Patients With Chronic Low Back Pain

Chronic Low-back Pain
University of Rzeszow80 enrolled1 locationNCT07463105
Recruiting
Phase 2

A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain

diabetic neuropathic painChronic Low-back PainOsteoarthritis, Knee
Eli Lilly and Company10,000 enrolled64 locationsNCT05986292
Recruiting
Not Applicable

High Frequency RF Current Effects on Muscle Pain and Function

Hamstring InjuryChronic Low-back PainPhysical Therapy+4 more
Aristotle University Of Thessaloniki200 enrolled2 locationsNCT05345015
Recruiting

Assessing Central Aspects of Pain

Chronic Low-back PainFibromyalgiaOsteoarthritis+1 more
University of Nottingham250 enrolled1 locationNCT06518278
Recruiting
Not Applicable

Evaluation of Stabilization Training With Biofeedback in Lumbosacral Spine Pain Syndrome

Chronic Low-back PainLow Back Pain
University of Rzeszow110 enrolled1 locationNCT07463729
Recruiting
Not Applicable

MBM and taVNS for Low Back Pain and Depressive Symptoms

Chronic Low-back Pain
Florida State University66 enrolled1 locationNCT07415941
Recruiting
Not Applicable

The Lumbar Interbody Fusion vs. Multidisciplinary Rehabilitation (LIFEHAB) Trial

Chronic Low-back Pain
Oslo University Hospital202 enrolled5 locationsNCT06169488
Recruiting
Phase 2

Modulation Effect of tACS on Chronic Low Back Pain

Chronic Low-back Pain
Massachusetts General Hospital80 enrolled1 locationNCT06568198
Recruiting
Not Applicable

Physical Exam, Static & Dynamic Ultrasound Assessment, & Treatment of Thoracolumbar Fascia (TLF) Mediated Low Back Pain

Chronic Low-back PainLow Back PainAcute low back pain
Edward Via Virginia College of Osteopathic Medicine200 enrolled1 locationNCT06818175