RecruitingNot ApplicableNCT06357845

Linking Somatic Mutation Rate With Baseline Exposure in East Palestine

Healthy Futures Research Study: Linking Somatic Mutation Rate With Baseline Exposure in East Palestine

Sponsor

Case Comprehensive Cancer Center

Enrollment

500 participants

Start Date

Aug 16, 2024

Study Type

INTERVENTIONAL

Conditions

Somatic Mutation

Summary

The goal of this study is to This research team is conducting this study to develop methods to measure the biological impact of exposure to the chemicals released following the February 3, 2023 train derailment on residents of East Palestine, Ohio, and surrounding communities. The main question it aims to answer is: * What biological impact will be measured based on DNA damage? * In participants who provide a biospecimen, how are biomarker changes related to proximity to the derailment and variations in residents' health histories and behaviors? Participants will: * Complete a brief survey asking about experiences related to the February 3, 2023 train derailment, health experiences, and concerns following the derailment, and background information regarding health history. * Possibly contribute biospecimens such as blood, spit, hair, and/or toenail clippings. * Receive communication about study updates and future research opportunities. * A total of 40 study participants will be recruited to participate in a 90-minute interview. The interviews will be video and audio recorded.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is examining whether people who lived near East Palestine, Ohio at the time of the February 2023 train derailment and chemical spill have higher rates of DNA mutations in their cells. Researchers want to understand the long-term health effects of exposure to toxic chemicals released in the disaster. **You may be eligible if...** - You lived in Columbiana County (OH), Mahoning County (OH), Beaver County (PA), or Lawrence County (PA) on February 3, 2023 — the date of the derailment - You currently live in the United States **You may NOT be eligible if...** - You did not live in one of the four qualifying counties on February 3, 2023 - You cannot provide a valid address for where you lived on that date Talk to your doctor to see if this trial is right for you.

This is a simplified summary. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERSurvey

Participants will complete a brief web-based survey asking about their experiences related to the February 3, 2023 train derailment, health experiences and concerns following the derailment, and background information regarding their health history. The survey will last approximately 15 minutes.

OTHERBiological specimen collection

Participants may possibly contribute biospecimens such as blood, spit, hair, and/or toenail clippings. Participants will be asked which samples they are interested in providing. Participants will receive a specific sample collection kit based on their selection. For blood samples, participants will receive a mailed collection kit at their mailing address. A member of the research team will reach out to schedule blood sample collection, which may take place at home with a trained phlebotomist or at a designated collection site. A total of 1-2 teaspoons of blood (5-10 milliliters) will be collected at a one-time blood draw. For either saliva, hair, and/or toenail clippings, participants will be sent a sample collection kit and receive instructions at their mailing address. This kit also includes a return mailing envelope. Participants will provide the selected samples in the collection kits, place them in the return mailing envelope, and send them back to the research team.

OTHERCommunications about study updates and future research opportunities

By consenting to participate in this study, the research team will send updates about the research results and any additional study opportunities to participants.

OTHERQualitative interview

A total of 40 study participants will be recruited to participate in a 90-minute interview with open-ended questions. The interviews will be video and audio-recorded.