RecruitingNCT06361784

Improving the Success Rate for Thoracic Radiotherapy Through Specific Cardiac Substructure Dosimetry: Location Matters. (LOCATION MATTERS)

"Improving the Success Rate for Thoracic Radiotherapy Through Specific Cardiac Substructure Dosimetry: Location Matters - a Prospective Study"

Sponsor

Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

Enrollment

150 participants

Start Date

Mar 29, 2024

Study Type

OBSERVATIONAL

Conditions

Locally Advanced Lung Non-Small Cell Carcinoma

Summary

The prospective study LOCATION MATTERS aims to investigate the radiation-induced damage to the heart and the cardiovascular system in patients treated with thoracic radiotherapy. Patients enrolled in the study will complete a set of extensive measures at the baseline, end of RT, and 9 months after treatment. Ultrasound exams, CT scans, pulmonary tests and wearable devices will assess functional and morphological parameters and the association with their variation and the dose delivered to the heart substructures and to the normal lung.

Eligibility

Plain Language Summary

Simplified for easier understanding

This study (LOCATION MATTERS) is investigating whether more precisely measuring the radiation dose delivered to specific parts of the heart during chest radiotherapy for lung cancer can better predict heart complications. By tracking where in the heart the dose lands — not just how much total dose is delivered — researchers hope to improve future treatment planning and protect heart health. **You may be eligible if...** - You have non-small cell lung cancer (NSCLC) - Your cancer is locally advanced (Stage 3) - You are receiving radiation therapy at Fondazione IRCCS Istituto Nazionale dei Tumori **You may NOT be eligible if...** - You have had previous radiation therapy to the chest - You have had prior heart surgery Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(1)

Fondazione IRCCS Istituto Nazionale dei Tumori

Milan, Italy

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NCT06361784

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