Impact of Sex in the Effect of Dietary Capsaicin on Cardiovascular Health
Impact of Sex in the Effect of Dietary Capsaicin on Cardiovascular Health: A Randomized Controlled Trial
Skidmore College
80 participants
Jul 8, 2024
INTERVENTIONAL
Conditions
Summary
The investigators long-term goal is to better understand novel interventions to promote cardiovascular health in humans. The goal of the proposed research is to investigate whether there is sex-specificity in the effects of dietary capsaicin on mechanisms regulating nitric oxide (NO) bioavailability, its effect on key markers of cardiovascular (CV) health, including BP, macro- and microvascular function, and arterial stiffness. This knowledge will provide critical insight into the effects of dietary capsaicin on CV health and will guide future trials.
Eligibility
Inclusion Criteria1
- relatively healthy (other than elevated blood pressure) non-smoking men and women over the age of 18 from the local community
Exclusion Criteria7
- Women who are without a period (not due to a birth control method, intrauterine device or menopause), are pregnant, attempting to conceive, or are breastfeeding will be excluded.
- uncontrolled hypertension
- Anyone with severe illness or compromised or suppressed immune system (e.g. taking immune suppressants, chronic viral infection or treatment).
- Any participants with excessive sensitivity to spicy foods or fiber (psyllium husk) will be excluded
- Participants with food allergies will be excluded
- Participants who have difficulty swallowing or swallowing pills may be excluded.
- Participants who suffer from heartburn, hiatal hernia, gastritis, or peptic ulcer disease may be excluded.
Interventions
Daily doses of dietary capsaicin or placebo in capsule form
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06363305