Spyral InSight Study

This study is evaluating a minimally invasive procedure called renal denervation — where nerves around the kidney arteries are treated to help lower blood pressure — in people whose high blood pressure is not well controlled with medication alone. **You may be eligible if...** - You are between 20 and 70 years old - You have high blood pressure (systolic 150–180 mmHg and diastolic at or above 90 mmHg) in the doctor's office - You are currently taking one, two, or three blood pressure medications - Your 24-hour blood pressure monitoring confirms elevated readings **You may NOT be eligible if...** - You have previously had a renal denervation procedure - You have a stent in your kidney artery or unsuitable kidney artery anatomy - Your kidney function is significantly reduced - You are taking SGLT2 inhibitors or GLP-1 receptor agonists (certain diabetes drugs) - You are pregnant, nursing, or planning to become pregnant - You have pulmonary hypertension or a secondary cause of high blood pressure - You are currently taking anti-mineralocorticoid medications Talk to your doctor to see if this trial is right for you.