RecruitingNCT06369766

REtinal Markers In Neuroinflammatory Diseases ("REMIND")

Retinal Markers in Neuroinflammatory Diseases: a Prospective Observational Study


Sponsor

University Hospital, Basel, Switzerland

Enrollment

500 participants

Start Date

Jan 31, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

The goal of this observational study, including patients with Multiple Sclerosis, patients with other neuroinflammatory diseases and healthy controls, is to determine the predictive value of retinal markers in predicting disease progression. Participants complete a questionnaire and undergo various non-invasive retinal routine clinical examinations.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at whether scans of the back of the eye (retina) can reveal clues about brain inflammation in people with Multiple Sclerosis or related nerve diseases. Researchers will use a special eye-imaging tool called OCT to track changes in the retina over time. **You may be eligible if...** - You are over 18 years old - You have been diagnosed with Multiple Sclerosis (MS), Neuromyelitis Optica (NMO), MOG antibody disease, or another neuroinflammatory condition - Healthy volunteers over 18 are also welcome to participate as a comparison group **You may NOT be eligible if...** - You have severe eye movement problems (like nystagmus) that prevent holding your gaze steady - You have eye conditions like cataracts, glaucoma, or very high short-sightedness - You are pregnant or breastfeeding - Healthy volunteers with a history of stroke, nerve inflammation, or other significant neurological conditions Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTOptical coherence tomography (OCT)

OCT is used to measure: * peripapillary retinal nerve fiber layer (mean thickness in μm) * ganglion cell-inner plexiform layer (volume in mm\^3 and mean thickness in μm) * other retinal layers (inner nuclear layer, outer plexiform layer, outer nerve layer; volumes in mm\^3 and mean thickness in μm). The "scanner laser ophthalmoscopy"-function of the OCT device is used to continuously record the exact location of each participant's fixation point in relation to their fovea and thereby allows the assessment of the fixation instability. In a subgroup of participants, the "angiography"-module of the OCT device is used to image the retinal blood flow and thereby allows to measure the vascular area density of the superficial retinal capillary plexus and deep retinal capillary plexus.

DIAGNOSTIC_TESTStatic retinal vessel analyzer

Static retinal vessel analyzer is used to determine: * central retinal arteriolar diameter equivalents (in μm) * central retinal venular diameter equivalents (in μm) * arteriolar-to-venular diameter ratio

DIAGNOSTIC_TESTDynamic retinal vessel analyzer

In a subgroup of participants, the dynamic retinal vessel analyzer is used to determine the arteriolar ficker light-induced dilatation, venular ficker light-induced dilatation, and Arteriolar constriction, measured in % dilatation in comparison to baseline.

DIAGNOSTIC_TESTLaser speckle flowgraphy system

In a subgroup of participants, the laser speckle flowgraphy system is used to measure the relative ocular blood flow as expressed in arbitary units of Mean Blur Rate.

OTHERQuestionnaire

All study participants will be asked to fill in a questionnaire with various questions regarding existing eye diseases, other diseases (including vascular diseases/risk factors), and daily physical activity that could influence the results of the retinal examinations. Physical activity will be assessed using an adapted form of the standardized Global Physical Activity Questionnaire.


Locations(1)

University Hospital Basel, Department of Neurology

Basel, Switzerland

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NCT06369766


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