RecruitingNot ApplicableNCT06373718

Sleep Mechanisms Of Regulating Emotions

A Novel Use of a Sleep Intervention to Target the Emotion Regulation Brain Network to Treat Depression and Anxiety (R33 Phase)

Sponsor

Stanford University

Enrollment

120 participants

Start Date

Aug 12, 2024

Study Type

INTERVENTIONAL

Conditions

Insomnia Depression

Summary

This project is the second phase of a two-phased project investigating the impact of a proven sleep intervention, Cognitive Behavioral Therapy for Insomnia (CBT-I) on engagement of the emotion regulation brain network as a putative mechanistic target.

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating how sleep problems affect emotional regulation in people with both insomnia and depression. Researchers at Stanford will use sleep monitoring and behavioral tasks to understand the brain and emotional mechanisms linking poor sleep to depression. **You may be eligible if...** - You are between 25 and 60 years old (any race or ethnicity) - You have significant insomnia (ISI score ≥ 10) lasting at least 3 months - You also have depressive symptoms (BDI score ≥ 14) - You can read and write in English - You live within 60 miles of Stanford University **You may NOT be eligible if...** - You have other sleep or circadian disorders (e.g., sleep apnea, restless legs) significantly causing your sleep problems - You are taking psychiatric medications that affect sleep and are unwilling to stop - You have a significant medical or psychiatric condition that would interfere with the study Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALCognitive Behavioral Therapy for Insomnia

CBT-I improves sleep through a combination of behavioral interventions (stimulus control (SC), sleep restriction (SR)), cognitive therapy (CT) as well as additional components such as mindfulness training and sleep hygiene education. SC is an intervention that re-establishes the connection between the bed/bedroom with sleep to help develop a more consistent sleep/wake pattern. SR leads to higher quality sleep by reducing excessive time spent in bed to the actual amount of sleep, thereby creating mild sleep deprivation and increasing the homeostatic sleep drive. Like CT for other disorders, CT for insomnia targets maladaptive thoughts and cognitions that may interfere with sleep.