RecruitingPhase 1NCT06375187

A Study of GC203 TIL in Advanced Malignant Solid Tumors

A Phase I Study to Evaluate the Safety and Efficacy of Engineering Tumor Infiltrating Lymphocytes Injection (GC203 TIL)in Patients With Advanced Malignant Solid Tumors


Sponsor

Shanghai Juncell Therapeutics

Enrollment

18 participants

Start Date

May 29, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

A clinical trial to assess the safety and efficacy of engineered Tumor Infiltrating Lymphocytes (TIL) for the treatment of Advanced Malignant Solid Tumors


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new type of cell therapy called GC203 TIL — a treatment made from your own immune cells — in people with advanced cancers that have spread and have not responded to standard treatments. **You may be eligible if...** - You are between 18 and 75 years old - You have advanced cancer that has spread (such as ovarian, endometrial, cervical, breast, gastrointestinal, or lung cancer) - Your cancer has already been treated with standard therapies (like chemotherapy, radiation, targeted therapy, or immunotherapy) and those treatments have stopped working - You have a tumor that can be safely biopsied or removed to make the cell therapy **You may NOT be eligible if...** - Your cancer has not yet tried standard treatments - Your tumor cannot be safely accessed for removal - You have severe organ problems or other serious health conditions Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALEngineering Tumor Infiltrating Lymphocytes

A tumor sample is resected from each participant and cultured ex vivo to generate the engineered tumor infiltrating lymphocytes. After lymphodepletion, patients are infused GC203 TIL followed low-dose PD-1 antibody.


Locations(1)

Fudan University Shanghai Cancer Center

Shanghai, China

View Full Details on ClinicalTrials.gov

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NCT06375187


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