Multicenter Cohort Study of ESD and Chemo-radiotherapy for High-risk Early-stage Esophageal Cancer

This study is looking at patients who had early-stage esophageal cancer removed through a procedure called endoscopic submucosal dissection (ESD) — a minimally invasive technique — and then received chemo-radiotherapy afterward instead of open surgery. Researchers want to assess the safety and effectiveness of this less-invasive approach. **You may be eligible if...** - You had early-stage esophageal cancer (pT1a-MM or pT1b stage) confirmed after ESD - You are eligible to receive chemotherapy and radiation - You declined surgery after your ESD procedure - You have signed informed consent **You may NOT be eligible if...** - You have severe heart, brain, lung disease, or kidney failure - You have a history of other cancers - You have received prior radiation or chemotherapy Talk to your doctor to see if this trial is right for you.