PeRforation EVents During ENdovascular Therapy for Acute Ischemic Stroke
PeRforation EVents During ENdovascular Therapy for Acute Ischemic Stroke (PREVENT) - Registry
University Hospital, Basel, Switzerland
1,000 participants
Dec 2, 2024
OBSERVATIONAL
Conditions
Summary
A large, worldwide study called PREVENT is looking at a complication that can happen during a stroke treatment called thrombectomy. This complication is a perforation of a blood vessel. The investigators aim to: 1. Find what factors make this perforation more likely. 2. Understand why the perforation happens by looking closely at images taken during the procedure. 3. Create a simple way to classify these perforations to help doctors decide how to treat them right away. 4. Improve the emergent treatment of vessel perforation to stop the bleeding rapidly. 5. Provide data to guide decision whether thrombectomy should be continued or aborted after the event of vessel perforation. 6. Develop a safer way to perform thrombectomy. Investigators will compare the results collected for patients where perforation happened with those where perforation did not happen.
Eligibility
Inclusion Criteria4
- Age ≥ 18 years at time of thrombectomy
- Acute ischemic stroke with occlusion of one or several intracranial arteries and subsequent thrombectomy.
- Target cohort: Occurrence of intracranial perforation during thrombectomy with evidence of contrast extravasation in at least one diagnostic angiography series.
- Comparison cohort: No perforation during thrombectomy. Every patient in the comparison group is matched to one patient in the target population. Matching will be carried out with respect to age, gender, participating center and location of the vascular occlusion.
Exclusion Criteria5
- Presence of a documented rejection
- Presence of both ischemic stroke and intracranial hemorrhage on pre-interventional imaging.
- Patients with intracranial dissection without active contrast extravasation.
- Patients with rupture of a pre-existing intracranial aneurysm during thrombectomy.
- Patients with contrast medium extravasation into a venous space instead of free contrast medium extravasation, e.g. the cavernous sinus with consecutive development of a carotid-cavernous fistula.
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Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06394180