RecruitingNCT06397677

Defining the Molecular and Radiologic Phenotype of Progressive RA Interstitial Lung Disease

Defining the Molecular and Radiologic Phenotype of Progressive RA Interstitial Lung Disease (MOUNTAIN)


Sponsor

University of Colorado, Denver

Enrollment

450 participants

Start Date

Jan 22, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

A study to identify patients with Rheumatoid Arthritis - Associated Interstitial Lung Disease (RA-ILD) that are at the highest risk for progression. The goal of the investigators is to recruit a group of patients with RA-ILD and collect information to help us understand more about disease progression. The investigators will do this using a combination of clinical, radiologic, and biologic features.


Eligibility

Min Age: 18 YearsMax Age: 90 Years

Plain Language Summary

Simplified for easier understanding

This research study aims to better understand the biological and radiological features (the "molecular and imaging fingerprint") of progressive lung disease that can occur in people with rheumatoid arthritis (RA) — a type called RA-ILD (interstitial lung disease). **You may be eligible if...** - You have a confirmed diagnosis of rheumatoid arthritis - You have been diagnosed with or are suspected of having interstitial lung disease (RA-ILD) - You are willing to provide blood and possibly tissue samples, and undergo lung imaging - You are at least 18 years old **You may NOT be eligible if...** - Your lung disease has a well-established alternative cause (e.g., drug-induced or another connective tissue disease) - You have severe limitations that prevent safe participation in the study procedures - You are unable to provide consent Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

GENETICResearch Testing Performed (Laboratory)

Blood collection (DNA, RNA)

DIAGNOSTIC_TESTInformation Collected as Standard of Care

High Resolution CT Scan (Chest), Pulmonary Function Testing (PFT), 6-Minute Walk Test (6MWT)

OTHERResearch Testing Performed

Blood collection (non-genetic), Buccal Swab, Rheumatologic Assessment, Pulmonary Assessment, Questionnaires


Locations(4)

University of California San Francisco

San Francisco, California, United States

University of Colorado Denver

Aurora, Colorado, United States

University of Kansas

Kansas City, Kansas, United States

University of Michigan

Ann Arbor, Michigan, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT06397677


Related Trials