RecruitingPhase 4NCT06401343

Use of SGLT2i in noHCM With HFpEF

Sodium-dependent Glucose Transporters 2 Inhibitor in Nonobstructive Hypertrophic Cardiomyoapthy Patients With Heart Failure With Preserved Ejection Fraction: a Prospective, Multi-center,Open-lable,Randomized Controlled Trial


Sponsor

China National Center for Cardiovascular Diseases

Enrollment

94 participants

Start Date

Aug 1, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

This study aims to evaluate the impact of Sodium-dependent glucose transporters 2 inhibitor Empagliflozin on the exercise capacity,symptoms of heart failure, cardiac function, myocardial remodeling and quality of life of nonobstructive HCM patients with HFpEF.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether SGLT2 inhibitor medications (a class originally developed for diabetes that also benefits the heart) can improve exercise capacity and symptoms in people with non-obstructive hypertrophic cardiomyopathy (a type of thickened heart muscle that doesn't block blood flow) who also have heart failure with preserved ejection fraction. **You may be eligible if...** - You are 18 or older - You have been diagnosed with non-obstructive hypertrophic cardiomyopathy - Your heart pumping function is at least 50% - You have elevated heart stress markers in your blood - You have mild to severe heart failure symptoms (NYHA class II–IV) - You can complete a stress test with adequate effort **You may NOT be eligible if...** - You have had septal reduction therapy (a procedure to reduce the thickened heart muscle) in the last 3 months - You had an acute worsening of heart failure in the past 3 months - Your blood pressure is too low or your kidneys are not functioning well - You have a significant blockage of blood flow out of the heart at rest or with exertion - You are pregnant or planning to become pregnant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGEmpagliflozin 10 MG

Participants randomized to the study group will received Empagliflozin 10mg q.d. for 12 months.


Locations(1)

Fuwai Hospital, National Centre for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College

Beijing, Beijing Municipality, China

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT06401343


Related Trials