RecruitingPhase 4NCT06402747

Clopidogrel Versus Cilostazol on Vessels

Comparing Clopidogrel and Cilostazol in Type 2 Diabetes Patients With Carotid Atherosclerosis


Sponsor

Seoul National University Bundang Hospital

Enrollment

120 participants

Start Date

Apr 16, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

Diabetes is an increasing cause of atherosclerotic and cardiovascular illnesses in South Korea. The clinical application of ultrasound for measuring carotid intima-media thickness, which helps in early detection and surveillance of atherosclerosis, is advancing. Due to lifestyle changes and an aging population, Koreans, especially diabetics, are developing more vascular diseases and are at higher risk for peripheral vascular disorders. Diabetics with lower limb peripheral artery disease require effective therapy to avoid major complications and a reduced quality of life. Although licensed for symptom control, Clopidogrel and Cilostazol have not yet been established for primary prevention of cardiovascular risks. These medications will be evaluated for their potential as primary preventive agents against cardiovascular disease in type 2 diabetes patients. The goal of this research is to investigate the efficacy of Cilostazol and Clopidogrel in inhibiting the progression of carotid atherosclerosis and to evaluate their influence on hemorheological changes in individuals with Type 2 diabetes. The goal of this research is to investigate the efficacy of Cilostazol and Clopidogrel in inhibiting the progression of carotid atherosclerosis and evaluating their influence on alterations in blood flow among individuals with Type 2 diabetes.


Eligibility

Min Age: 19 Years

Plain Language Summary

Simplified for easier understanding

This study compares two anti-platelet medications — clopidogrel and cilostazol — in people with diabetes who show early signs of blood vessel thickening in the neck (carotid artery). The goal is to find out which drug is better at slowing down this process and reducing cardiovascular risk. **You may be eligible if...** - You are 19 years or older and have diabetes - An ultrasound has shown early thickening of your carotid artery (a measurement of 1.0mm or more) - Your blood sugar (HbA1c) is 10% or below - Your current medications have not changed in the past 3 months **You may NOT be eligible if...** - You are currently taking blood thinners or anti-clotting medications (other than aspirin) - You have a bleeding disorder, history of stroke in the past 6 months, recent surgery, or uncontrolled high blood pressure - You have had a heart attack, unstable angina, or heart bypass in the past 6 months - You have severe kidney or liver disease, or heart failure - You are pregnant or breastfeeding - You are allergic to either study drug Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGClopidogrel

Clopidogrel 75mg once daily

DRUGCilostazol

Cilostazol 200mg per day


Locations(1)

Seoul National University Bundang Hospital

Seongnam-si, Gyeonggi-do, South Korea

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT06402747


Related Trials