VIsualization of Coronary Artery Disease for Modification of RISK Factors
VIsualization of Coronary Artery Disease for Modification of RISK Factors. Prevention of Disease Progression in Patients With Non-Obstructive Coronary Atherosclerosis.
Aarhus University Hospital
273 participants
Mar 12, 2024
INTERVENTIONAL
Conditions
Summary
The VICAD-RISK study assesses if visualization of coronary CT angiography (CTA) images in participants with non-obstructive coronary artery disease will improve LDL lowering, reduce reporting of side effects by cholesterol lowering medications, and modify the coronary artery disease phenotype over 12 months.
Eligibility
Inclusion Criteria6
- New diagnosis of nonobstructive coronary artery disease
- No known coronary artery disease (no previous coronary revascularization)
- CAD-Rads score 1-3
- LDL cholesterol \> 2.0 mmol/l
- Life expectancy \>3 years
- Signed informed consent
Exclusion Criteria10
- Post CTA test indication for invasive coronary angiography
- Non-evaluable CTA exam
- Obstructive coronary disease (One or more coronary stenosis ≥70%, left main \>40%)
- Ongoing lipid lowering medical treatment (Patients already on lipid lowering medical therapy can be included if the treatment was initiated \<3 months before the time of the CTA test)
- BMI \>40
- Renal insufficiency (eGFR \<40 ml/min)
- Allergy to iodinated contrast media
- Contraindications to statins (Active liver disease Child-Pugh A, B and C, excessive alcohol consumption)
- Participation in a cardiac rehabilitation or lifestyle modification program
- Pregnancy
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Interventions
As described before
As described before
As described before
Locations(5)
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NCT06413641