Fish Oil, Metformin and Heart Health in PCOS
Dietary Fish Oil and Metformin Intervention for Heart Health in PCOS
University of Alberta
146 participants
Nov 1, 2025
INTERVENTIONAL
Conditions
Summary
Women with Polycystic Ovary Syndrome (PCOS) have high testosterone levels which is associated with altered insulin-glucose metabolism and an adverse blood lipid profile, predisposing them to the development of Type II Diabetes and Cardiovascular Disease (CVD). This study will investigate the use of dietary fish oil supplementation as a safe and effective intervention, and as an adjunct therapy to standard of care treatment with metformin to improve heart health, blood lipids and insulin-glucose metabolism in women with PCOS, and those with PCOS and Type 2 Diabetes.
Eligibility
Inclusion Criteria5
- diagnosis of PCOS
- overweight-obese (BMI \>25 kg/m2)
- elevated fasting plasma TG (\>150 mg/dL)
- and/or apoB48-remnant cholesterol lipoproteins (\>20 ug/ml)
- impaired insulin sensitivity (glucose 100-125 mg/dL and/or insulin \>15 (uM/ml), and may be diagnosed with T2D (blood glucose \>126 mg/dL).
Exclusion Criteria1
- pregnancy, lactation
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Interventions
For 12 months
12 months
12 months
Locations(3)
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NCT06424860