RecruitingNCT06427018

Expressions of Ezrin and Pip5k1α Proteins in Airway Smooth Muscle of Asthmatic Patients

Assessing the Expressions of Ezrin, Phosphorylated Ezrin, and Pip5k1α in the Airway Smooth Muscle of Asthmatic Patient

Sponsor

Lei-Miao Yin

Enrollment

120 participants

Start Date

May 28, 2024

Study Type

OBSERVATIONAL

Conditions

Asthma Protein

Summary

Asthma, a prevalent chronic respiratory affliction, significantly impinges upon the quality of life for affected individuals. Timely and appropriate diagnostic measures, coupled with efficacious therapeutic interventions, are paramount in mitigating exacerbations of symptoms and enhancing the life quality of patients. Ezrin plays an important role in maintaining cell morphology, cell migration, cell adhesion and polarisation, but Ezrin expression in airway smooth muscle remains unclear. Pip5k1α is an important kinase involved in intracellular phosphatidylinositol signalling pathways that may be involved in smooth muscle contraction and diastole. Therefore, further studies are necessary to elucidate the changes of Ezrin and Pip5k1α in patients with asthma to provide a basis for investigating alternative treatments for asthma.

Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This is a laboratory study examining the levels of two proteins — Ezrin and Pip5k1α — in the airway smooth muscle tissue of asthmatic patients compared to non-asthmatic patients. The goal is to better understand the molecular basis of airway tightening in asthma. **You may be eligible if...** - You are between 18 and 70 years old - You underwent lung tissue sampling as part of your treatment (e.g., during surgery) - Your tissue sample includes airway smooth muscle - You have been diagnosed with bronchial asthma — OR — you are a non-asthmatic patient (for comparison) **You may NOT be eligible if...** - You have been diagnosed with COPD (chronic obstructive pulmonary disease) - Your tissue sample does not meet the quality or type needed for the study Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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