RecruitingNot ApplicableNCT06428721

The Preventive Role of Fractionated Laser Resurfacing Against Actinic Neoplasia in an At-Risk Geriatric Population

Sponsor

Wright State University

Enrollment

80 participants

Start Date

Mar 20, 2024

Study Type

INTERVENTIONAL

Conditions

Non-melanoma Skin Cancer Aging Actinic Keratoses

Summary

The purpose of this study is to determine if the Fractionated Laser Resurfacing (FLR) procedure can protect one forearm/wrist from precancerous actinic keratosis (AKs) as well as prevent skin cancer in older subjects with active AKs. This study builds on a similar study ongoing at the Dayton Veterans Administration dermatology clinic. This study is also testing if a photograph of the skin can be used to predict where the AKs and an skin cancers will form.

Eligibility

Min Age: 60 Years

Inclusion Criteria5

Adult Males and Females aged 60 and older
Have at least 5 AKs on each forearm/wrist, but no more than 10 to allow for easy monitoring
Skin type fair (Fitzpatrick I-II)
Females must be post-menopausal and not be on systemic hormone replacement therapy
Able to comprehend procedures and risks

Exclusion Criteria10

More than 10 AKs on an extremity
AKs that are large (2-3+, hyperkeratotic grade 3 lesions)
AKs that are very thick (\>3 mm)
Medical history of diabetes
History of poor wound healing or scarring
Large tattoos that can interfere with study
Other serious health issues and other skin diseases that could interfere with the study
Recent (within 1 year) field therapies such as efudex cream or PDT to forearms/wrists.
Planning to leave region in next 5 years
Subjects with allergies to xylocaine will be excluded if they need this topical anesthetic.