The Preventive Role of Fractionated Laser Resurfacing Against Actinic Neoplasia in an At-Risk Geriatric Population

This study is testing whether a fractional laser skin treatment (a type of laser that creates tiny columns of controlled skin damage to stimulate healing) can prevent precancerous skin lesions called actinic keratoses (AKs) from developing further in older adults with sun-damaged skin who are at high risk for skin cancer. **You may be eligible if...** - You are a man or woman aged 60 or older - You have between 5 and 10 actinic keratoses (rough, scaly patches from sun damage) on each forearm or wrist - You have fair skin (Fitzpatrick skin type I or II) - You are female and post-menopausal and not on hormone replacement therapy - You understand what the study involves and can give consent **You may NOT be eligible if...** - You have more than 10 actinic keratoses on an arm - Your lesions are large, very thick, or severely raised - You have diabetes - You have a history of poor wound healing or abnormal scarring - You have large tattoos that could interfere with tracking the lesions - You have had field treatments (like fluorouracil cream or photodynamic therapy) on your forearms in the past year - You plan to move out of the region in the next 5 years Talk to your doctor to see if this trial is right for you.