Effects of Different Doses of Intravenous Lidocaine Infusion on Peri-operative Pain and Incidence of Postoperative Chronic Pain Within ERAS Protocols, a Dose Finding Study.
Cairo University
69 participants
Mar 15, 2024
INTERVENTIONAL
Summary
This study aimed To investigate the effects of different doses of Intraoperative intravenous lidocaine infusion on intraoperative opioid consumption, perioperative pain control and incidence of postoperative chronic pain.
Eligibility
Inclusion Criteria3
- Patients age between 18 and 65.
- Patients with ASA I and II status.
- Patients undergoing open laparotomy surgeries (including open cholecystectomies).
Exclusion Criteria4
- Patients unable to comprehend the informed consent.
- Patients on long term pre-operative opioid regimens.
- Patients with impairment in hepatic or renal functions.
- Patients who are planned to receive any form of regional block for the surgery.
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Interventions
After confirming patient history, type of operation and patient group allocation, standard ASA monitoring will be attached to the patient then the I.V induction of anesthesia will be commenced using standard doses of Propofol \&Tracrium in addition to 1 μg/kg Fentanyl and 1 ml/10 kg from the bolus Lidocaine syringe followed after 3 minutes by endotracheal intubation, then the Lidocaine infusion Syringe will be attached to a separate I.V line at an infusion rate of 1 ml/10 kg/h. The patient will receive 1 gm of I.V paracetamol and the surgery will be allowed to proceed.
Locations(1)
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NCT06431165