RecruitingNot ApplicableNCT06764667

Comparison of Spinal Anesthesia Adjuvant and Quadratus Lumborum Block on the Opioid Requirement and Perioperative Pain of Laparoscopic Kidney Transplant Donor


Sponsor

Indonesia University

Enrollment

60 participants

Start Date

Feb 10, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This study aims to compare the effectiveness of spinal anesthesia adjuvant and quadratus lumborum block on the opioid requirement and perioperative pain on patients undergoing laparoscopic kidney transplant donor.


Eligibility

Min Age: 18 YearsMax Age: 65 Years

Inclusion Criteria4

  • Patients aged 18-65 years undergoing laparoscopic donor nephrectomy
  • Patients with BMI ≤ 35 kg/m2
  • Patients with American Society of Anesthesiology (ASA) physical status 1-2
  • Patients who are willing to participate in this study

Exclusion Criteria7

  • Cardiovascular disease (uncontrolled stage 2 hypertension, heart failure, arrhytmia)
  • Recent onset cerebrovascular diseasae of < 3 months
  • Infection on spinal site
  • Coagulopathy
  • Elevated intracranial pressure
  • Severe renal or liver dysfunction
  • Valvular heart disease or atrioventricular block

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Interventions

PROCEDURESpinal anesthesia adjuvant

Patients in this arm will receive 10 mg 0.5% hyperbaric Bupivacaine, 100 mcg Morphine, 100 mcg Sulfas Atropine, and 0.9% normal saline to total volume of 4 ml before induction of anesthesia.

PROCEDUREQuadratus Lumborum Block (QLB)

Patients in this arm will receive quadratus lumborum block with 20-30 ml of 0.25% Bupivacaine after induction of anesthesia and after operation.

PROCEDUREGeneral Anesthesia

The subject will undergo preoxygenation with 100% oxygen for 3 minutes. Following preoxygenation, anesthesia induction will be performed using lidocaine at a dose of 1.5 mg/kg, fentanyl at 1.5 mcg/kg, and propofol at 2.0 mg/kg. Once the subject is adequately sedated, baseline neuromuscular monitoring using the train-of-four (TOF) technique will be conducted, followed by the administration of rocuronium at a dose of 0.8 mg/kg. Endotracheal intubation will be performed using direct laryngoscopy once the TOF value reaches 0, utilizing an appropriately sized endotracheal tube (ETT). Ten milligrams of intravenous dexamethasone is administered after induction.


Locations(1)

RSUP dr. Cipto Mangunkusumo

Jakarta Pusat, Jakarta Special Capital Region, Indonesia

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NCT06764667