Comparison of Spinal Anesthesia Adjuvant and Quadratus Lumborum Block on the Opioid Requirement and Perioperative Pain of Laparoscopic Kidney Transplant Donor
Indonesia University
60 participants
Feb 10, 2025
INTERVENTIONAL
Conditions
Summary
This study aims to compare the effectiveness of spinal anesthesia adjuvant and quadratus lumborum block on the opioid requirement and perioperative pain on patients undergoing laparoscopic kidney transplant donor.
Eligibility
Inclusion Criteria4
- Patients aged 18-65 years undergoing laparoscopic donor nephrectomy
- Patients with BMI ≤ 35 kg/m2
- Patients with American Society of Anesthesiology (ASA) physical status 1-2
- Patients who are willing to participate in this study
Exclusion Criteria7
- Cardiovascular disease (uncontrolled stage 2 hypertension, heart failure, arrhytmia)
- Recent onset cerebrovascular diseasae of < 3 months
- Infection on spinal site
- Coagulopathy
- Elevated intracranial pressure
- Severe renal or liver dysfunction
- Valvular heart disease or atrioventricular block
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Interventions
Patients in this arm will receive 10 mg 0.5% hyperbaric Bupivacaine, 100 mcg Morphine, 100 mcg Sulfas Atropine, and 0.9% normal saline to total volume of 4 ml before induction of anesthesia.
Patients in this arm will receive quadratus lumborum block with 20-30 ml of 0.25% Bupivacaine after induction of anesthesia and after operation.
The subject will undergo preoxygenation with 100% oxygen for 3 minutes. Following preoxygenation, anesthesia induction will be performed using lidocaine at a dose of 1.5 mg/kg, fentanyl at 1.5 mcg/kg, and propofol at 2.0 mg/kg. Once the subject is adequately sedated, baseline neuromuscular monitoring using the train-of-four (TOF) technique will be conducted, followed by the administration of rocuronium at a dose of 0.8 mg/kg. Endotracheal intubation will be performed using direct laryngoscopy once the TOF value reaches 0, utilizing an appropriately sized endotracheal tube (ETT). Ten milligrams of intravenous dexamethasone is administered after induction.
Locations(1)
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NCT06764667