RecruitingNot ApplicableNCT06438419

Parkinsonism-Related Oscillations in the Cortico-Basal Ganglia-Thalamic Network During Movement: Beyond the Frequency Range


Sponsor

University Hospital, Bordeaux

Enrollment

20 participants

Start Date

Apr 16, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

Expression of hypokinetic and hyperkinetic motor symptoms in Parkinson's disease (PD) is associated with pathological synchronous oscillations of neuronal activity (local field potential/LFP) in the cortico-subcortical network with a wide frequency range. In the present project, we propose to study cortico-subcortical oscillations and their synchronization in patients operated for PD (subthalamic deep brain stimulation (STN-DBS)) during distinct pharmacological and stimulation conditions (hypokinetic and hyperkinetic), using a simple motor task.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study records brain and movement signals in patients with Parkinson's disease who have a deep brain stimulation (DBS) device implanted in an area called the subthalamic nucleus (STN). Researchers want to understand the abnormal brain wave patterns (oscillations) that cause movement difficulties and how they change during activity. **You may be eligible if...** - You are between 18 and 75 years old with idiopathic (standard, non-genetic) Parkinson's disease - You have recently received a PERCEPT™ deep brain stimulation device (within the last year) or you are scheduled to receive one - You are able to perform a simple motor task - You have health insurance coverage - You are able to provide written informed consent **You may NOT be eligible if...** - You are unable to give consent personally - You are under legal guardianship or court-ordered protection - You are pregnant or breastfeeding - You have a serious uncontrolled physical or psychiatric illness Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERElectrophysiological recordings

Electrophysiological recordings will be made during a motor task in four different conditions: 1. without pharmacological treatment and without stimulation (Off condition), 2. without pharmacological treatment and during stimulation (DBS condition), 3. during pharmacological treatment and without stimulation (DOPA condition), 4. during pharmacological treatment and stimulation (DOPA+DBS condition).


Locations(1)

Bordeaux University Hospital

Bordeaux, France

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NCT06438419


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