Psilocybin Therapy for Depression in Parkinson's Disease

This study is testing whether psilocybin (a compound found in certain mushrooms) can help reduce depression in people who have Parkinson's disease. Researchers want to understand if this type of therapy is safe and effective for this specific group. **You may be eligible if...** - You are between 40 and 80 years old - You have been diagnosed with Parkinson's disease by a neurologist - Your Parkinson's is in an early-to-moderate stage (stages 1–3) - You are currently experiencing symptoms of depression - You are comfortable speaking and writing in English - You can travel to UCSF for in-person visits and join virtual appointments - You have an active doctor (primary care, neurologist, or psychiatrist) managing your care **You may NOT be eligible if...** - You are experiencing psychosis or have lost touch with reality - You have significant memory or thinking problems - You take medications that could interact badly with psilocybin - You have a health condition that makes participation unsafe Talk to your doctor to see if this trial is right for you.