RecruitingPhase 2NCT06455293
Psilocybin Therapy for Depression in Parkinson's Disease
The Efficacy of Psilocybin Therapy for Depression in Parkinson's Disease
Sponsor
Joshua Woolley, MD, PhD
Enrollment
60 participants
Start Date
Aug 19, 2024
Study Type
INTERVENTIONAL
Conditions
Summary
The purpose of this study is to understand whether people with Parkinson's Disease and depression have improvement in their symptoms after psilocybin therapy.
Eligibility
Min Age: 40 YearsMax Age: 80 Years
Inclusion Criteria6
- Age 40 to 80
- Comfortable speaking and writing in English
- Have neurologist-diagnosed idiopathic Parkinson's disease (PD), Hoehn and Yahr stages 1 to 3 during an "on" phase (time when medication/DBS for parkinsonian motor feature, including bradykinesia and rigidity is in effect)
- Currently experiencing depressive symptoms
- Able to attend all in-person visits at UCSF as well as virtual visits
- Have a primary care provider, neurologist, or psychiatrist who is actively managing or coordinating
Exclusion Criteria4
- Psychotic symptoms involving loss of insight
- Significant cognitive impairment
- Regular use of medications that may have problematic interactions with psilocybin
- A health condition that makes this study unsafe or unfeasible, determined by study physicians
Interventions
DRUGPsilocybin
Single dose of psilocybin ranging from low ("microdose") to high delivered orally with psychological support and monitoring
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06455293
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