RecruitingNot ApplicableNCT06455371

Patient-centered Dosage of Levothyroxine

Patient-centered Decision Support Tool for Levothyroxine Dosage

Sponsor

University Hospital of North Norway

Enrollment

240 participants

Start Date

Dec 20, 2024

Study Type

INTERVENTIONAL

Conditions

Thyroid Cancer Thyroid Hypothyroidism

Summary

Levothyroxine is the most used thyroid hormone replacement when the thyroid gland is failing. Because dosage adjustment normally takes several months, the investigators have developed a decision support tool (DST) that predicts optimal dosage based on repeated blood samples the first 2 weeks after initiation of therapy. In this randomized study the investigators will include patients that start levothyroxine therapy after total thyroidectomy. The use of DST to advice the physician about an early dosage adjustment will be compared with common clinical practice, that is dosage adjustment every 2 months. The effect of DST use will be assessed by studying the possible relationship between fast optimal dose adjustment, patient reported outcome measures, and ability to work.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at how to find the best thyroid hormone (levothyroxine) dose for each individual patient after their thyroid has been removed. Currently, doctors use standard formulas, but this study wants to see if a more personalized approach improves how patients feel. **You may be eligible if...** - You had your entire thyroid removed (total or completion thyroidectomy) at a Norwegian hospital - The reason was either differentiated thyroid cancer or a benign (non-cancerous) thyroid nodule **You may NOT be eligible if...** - You have anaplastic (very aggressive) thyroid cancer - Your thyroid cancer has spread to distant parts of the body - You have Graves' disease or toxic thyroid nodules - You are pregnant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERDecision support tool

Patients in the intervention groups are given the option to use the decision support tool when adjusting the levothyroxine dose after total thyroidectomy. Levothyroxine therapy is not a part of the intervention, as all patients receive this therapy regardless of study participation.

Locations(3)

Haukeland University Hospital

Bergen, Norway

Oslo University Hospital

Oslo, Norway

University Hospital of North Norway

Tromsø, Norway

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NCT06455371

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