RecruitingNot ApplicableNCT06467552

Effects of Nutritional Support on Postoperative Delirium

Effects of Nutritional Support on Postoperative Delirium (POD) in Elderly Non-cardiac Surgical patients_non-inferiority Comparison

Sponsor

Yonsei University

Enrollment

314 participants

Start Date

Jun 1, 2024

Study Type

INTERVENTIONAL

Conditions

Postoperative Delirium

Summary

This study is a prospective, single-center, randomized controlled trial to compare whether applying nutritional supplementation therapy before and after surgery in elderly patients aged 65 years or older undergoing non-cardiac surgery can reduce the incidence of postoperative delirium.

Eligibility

Min Age: 65 Years

Inclusion Criteria4

Elderly patients aged 65 and above.
Patients undergoing non-cardiac major surgery in thoracic surgery, lung cancer surgery, multi-level spinal surgery in neurosurgery and orthopedics, or liver cancer surgery in hepatobiliary and pancreatic surgery, under general anesthesia with an expected surgery duration of 2 hours or more.
Patients scheduled for arterial catheterization.
Patients who are able to take oral intake from postoperative day #1.

Exclusion Criteria8

Patients with uncontrolled systemic conditions such as diabetes, hypertension, renal disease, liver disease, and other systemic illnesses.
Those with visual impairment.
Patients with cognitive impairment based on the Mini-Mental State Examination for Dementia Screening criteria.
Individuals experiencing difficulty in communication.
Those diagnosed with neurological disorders (such as brain hemorrhage, stroke, brain tumor, dementia, Parkinson's disease, cognitive impairment, depression, etc.).
Patients diagnosed with alcohol or substance addiction.
Patients with cancelled scheduled surgeries.
Patients undergoing minor surgeries with expected anesthesia durations of less than 2 hours.

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Interventions

PROCEDUREcontrol group

The entire process is carried out according to Severance Hospital surgical protocols.

DIETARY_SUPPLEMENTNucare Curact group

The entire process is carried out according to Severance Hospital surgical protocols. The patients of control group will receive education from the research team about the importance of nutrition and exercise before and after surgery. In addition, the patients of control group will be instructed to take up to 4 doses of the nutritional supplement (Nucare Curact provided by DAESANG Wellife Inc.) per day for approximately 2 weeks before surgery and for about 4 weeks after surgery.