Deep Neuromuscular Block Affect the Quality of Recovery After Laparoscopic Hysterectomy
Effect of Deep Neuromuscular Block on the Quality of Recovery After Laparoscopic Hysterectomy
Anqing Municipal Hospital
72 participants
Jun 25, 2024
INTERVENTIONAL
Conditions
Summary
BACKGROUND: Some studies have revealed that deep neuromuscular block (NMB) improve surgical conditions and alleviated postoperative pain compared with moderate NMB. The present study investigated deep NMB could improve the quality of recovery after laparoscopic hysterectomy METHODS: seventy-two women with elective laparoscopic hysterectomy were randomly divided into 2 groups: Patients in group A received low-pressure pneumoperitoneum (LPP), which was set at 8-10 mmHg with deep NMB. Patients in group B received standard-pressure pneumoperitoneum (SPP), which was set at 12-14 mmHg with moderate NMB. Primary outcome was the quality of recovery (QoR-15) at 1 day after sugery. The secondary outcomes included postoperative pain, surgical condition, incidence of shoulder pain, the incidence of rescue analgesic drug use, cumulative dose of analgesics, time of first flatus, post-operative nausea and vomiting, time of tracheal tube removal.
Eligibility
Inclusion Criteria2
- American Society of Anesthesiologists (ASA) physical status Ⅰ- Ⅲ
- Scheduled for elective laparoscopic hysterectomy
Exclusion Criteria6
- Inability to give informed consent
- BMI >35
- Renal or hepatic insufficiency
- History of preoperative psychiatric
- Previous surgery at procedure site
- Neuromuscular disease, pregnancy, and contraindications to study medications.
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Interventions
low-pressure pneumoperitoneum (LPP) with deep NMB.
standard-pressure pneumoperitoneum (SPP) with moderate NMB.
Locations(1)
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NCT06469866