Biopsychosocial Predictors of Nicotine Relapse
Identifying Biomarkers of Stress-induced Neurophysiological Changes and Emotion Regulation Deficits to Predict Relapse During Nicotine Abstinence
University of Cyprus
200 participants
Jan 1, 2022
INTERVENTIONAL
Conditions
Summary
This study aims to investigate the associations between emotion regulation ability, stress-induced neural activity changes, and susceptibility to relapse in smokers attempting to quit. Participants will undergo assessments of emotion regulation, neural activity via quantitative electroencephalography (qEEG), and stress responses before and during a 24-hour nicotine abstinence period. They will then participate in a computerized smoking cessation intervention, and their abstinence status will be monitored for 6 months.
Eligibility
Inclusion Criteria4
- Age 18-60 years
- Smoking at least 10 cigarettes daily for at least 2 years
- Intention to quit smoking
- Medication-free
Exclusion Criteria6
- Presence of psychiatric or medical treatment
- Pregnancy
- Current unstable medical illness
- Recent (prior 6 months) drug or alcohol use disorder
- Major Depression
- Diagnosis of psychotic disorder
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Interventions
Flexiquit is an avatar-led, self-directed computerized program delivering evidence-based techniques to assist with smoking cessation. It includes motivational interviewing, psychoeducation on nicotine addiction, cognitive-behavioral strategies for coping with cravings, relapse prevention, and stress/emotion regulation skills training. Participants receive the program over 6 months and their adherence is monitored. The program provides tailored feedback to support abstinence.
Locations(1)
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NCT06470321